| Chapter title |
Endocannabinoids
|
|---|---|
| Chapter number | 15 |
| Book title |
Endocannabinoids
|
| Published in |
Handbook of experimental pharmacology, January 2015
|
| DOI | 10.1007/978-3-319-20825-1_15 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-920824-4, 978-3-31-920825-1
|
| Authors |
Izzo, Angelo A, Muccioli, Giulio G, Ruggieri, Michael R, Schicho, Rudolf, Angelo A. Izzo, Giulio G. Muccioli, Michael R. Ruggieri, Rudolf Schicho, Izzo, Angelo A., Muccioli, Giulio G., Ruggieri, Michael R. |
| Editors |
Roger G. Pertwee |
| Abstract |
Components of the so-called endocannabinoid system, i.e., cannabinoid receptors, endocannabinoids, as well as enzymes involved in endocannabinoid synthesis and degradation, have been identified both in the gastrointestinal and in the urinary tract. Evidence suggests that the endocannabinoid system is implicated in many gastrointestinal and urinary physiological and pathophysiological processes, including epithelial cell growth, inflammation, analgesia, and motor function. A pharmacological modulation of the endocannabinoid system might be beneficial for widespread diseases such as gastrointestinal reflux disease, irritable bowel syndrome, inflammatory bowel disease, colon cancer, cystitis, and hyperactive bladder. Drugs that inhibit endocannabinoid degradation and raise the level of endocannabinoids, non-psychotropic cannabinoids (notably cannabidiol), and palmitoylethanolamide, an acylethanolamide co-released with the endocannabinoid anandamide, are promising candidates for gastrointestinal and urinary diseases. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 59 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 16% |
| Student > Ph. D. Student | 8 | 13% |
| Student > Master | 8 | 13% |
| Other | 7 | 11% |
| Student > Bachelor | 6 | 10% |
| Other | 8 | 13% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
| Agricultural and Biological Sciences | 5 | 8% |
| Psychology | 4 | 7% |
| Other | 9 | 15% |
| Unknown | 19 | 31% |