Human Tumour Xenografts in Anticancer Drug Development

Table of Contents

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   Book Overview
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   Chapter 1 The Therapeutic Response of a Variety of Human Tumour Xenografts
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   Chapter 2 Biology of Human Ovarian Cancer Xenografts
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   Chapter 3 Representativity of Xenografts for Clinical Cancer. Tumor and Host Characteristics as Variables of Tumor Take Rate
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   Chapter 4 Comparison of Tumor Response in Nude Mice and in Patients
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   Chapter 5 Conventional Agents in Human Ovarian Cancer Xenografts
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   Chapter 6 Activity of Conventional Drugs in Head and Neck Cancer Xenografts
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   Chapter 7 Preclinical Drug Evaluation with Human Melanoma Xenografts
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   Chapter 8 Lung Xenografts as a Predictive Screen for Antineoplastic Agents
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    Chapter 9 Chemotherapy Studies in Human Non-Small Cell Lung Cancer Xenografts Transplanted in Immune-Deprived Mice
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    Chapter 10 Establishment and Response to Chemotherapy of Human Cervical Carcinoma Xenografts
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    Chapter 11 The Usefulness of the Nude Mouse Model for Predicting the Chemosensitivity of Human Tumors. Studies in Malignant Melanoma
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    Chapter 12 Screening of Analogs in Human Ovarian Cancer Xenografts
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    Chapter 13 Predictability of Clinical Response of Several Human and Murine Tumor Models to Four Anthracycline Derivatives
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    Chapter 14 Activity of Six New Drugs in Head and Neck Cancer Xenografts
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    Chapter 15 Activity of Metallocene Complexes Against Human Tumours Heterotransplanted into Athymic Mice
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    Chapter 16 The Effect of Human and Murine Interferons on Human Tumour Xenografts
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    Chapter 17 Biodistribution and Therapeutic Efficacy of a Monoclonal Antibody-Methotrexate Conjugate in Mice
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    Chapter 18 The Effect of Interferon-Alpha on the Activity of Cytotoxic Drugs in Bronchial Carcinoma Xenografts
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    Chapter 19 The Nude Mouse for the Study of Immunotoxins
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    Chapter 20 Proposal for the Application of Xenografts in Screening for New Anticancer Agents and in Selecting Tumor Types for Phase II Clinical Trials
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    Chapter 21 Human Tumour Xenograft Models for Use with an In Vitro-Based, Disease-Oriented Antitumour Drug Screening Program
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    Chapter 22 Mechanisms of Drug Resistance in Screening
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    Chapter 23 Circumvention of Inherent Resistance with Verapamil in a Human Tumour Xenograft
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    Chapter 24 Clonogenic Assay Screening Study Group (CASSG): Contribution to an EORTC Drug Screening Programme
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    Chapter 25 Polyamine Uptake by Malignant Brain Tumour Xenografts in Nude Mice
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    Chapter 26 The Activity for a Novel Niteosourea (TCNU) in Human Lung Cancer Xenografts
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    Chapter 27 Xenografts in Pharmacologically Immunosuppressed Mice as a Model to Test the Chemotherapeutic Sensitivity of Human Tumours
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    Chapter 28 New Tissue-Specific Metastasis Models in Adult Nude Mice
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    Chapter 29 Fractionated Irradiation of Human Tumor Xenografts in Athymic Nude Mice
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    Chapter 30 An Animal Model for Human Tumor Xenografts
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    Chapter 31 Xenografted Human Tumors in Preclinical Drug Design
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    Chapter 32 Growth in Nude Mice of a T-Cell Line from a Case of Acute Lymphoblastic Leukaemia: A Model for Experimental Immunotherapy of Human Neoplasia
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    Chapter 33 5-Fluorouracil (5-FU) + Cis-diamminedichloroplatinum (DDP) Treatment of Human Colorectal Tumor Xenografts
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    Chapter 34 Inter and Intra-Tumor Variation in the Response to Chemotherapy of Human Small Cell Carcinoma of the Lung (SCCL) Grown in Nude Mice
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    Chapter 35 Human Carcinoma Cell Lines Xenografted in Athymic Mice: Biological and Antigenic Characterization of an Intra-Abdominal Model
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    Chapter 36 Squamous Cell Carcinoma Xenografts as a Model for the Study of Drug-Induced Cell Kinetic Changes in Head and Neck Cancer