Chapter 1 History of the Thymus: From a Vestigial Organ to the Programming of Immunological Self-Tolerance

Chapter 2 Thymus Ontogeny and Development

Chapter 3 The Ins and Outs of Thymic Epithelial Cell Differentiation and Function

Chapter 4 T-Cell Development: From T-Lineage Specification to Intrathymic Maturation

Chapter 5 Intrathymic Cell Migration: Implications in Thymocyte Development and T-Cell Repertoire Formation

Chapter 6 Thymic Crosstalk: An Overview of the Complex Cellular Interactions That Control the Establishment of T-Cell Tolerance

Chapter 7 The Autoimmune Regulator ( AIRE ) Gene, the Master Activator of Self-Antigen Expression in the Thymus

Chapter 8 Aire Mutations and Autoimmune Diseases

Chapter 9 The Thymus as a Mirror of the Body’s Gene Expression

Chapter 10 Functional Genomics of the Infant Human Thymus: AIRE and Minipuberty

Chapter 12 Development of Thymic Regulatory T Lymphocytes

Chapter 13 Adding Insult to Injury: Improving the Regenerative Capacity of the Aged Thymus Following Clinically Induced Damage

Chapter 14 Thymus Rejuvenation After Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases