Chapter title |
Understanding Molecular Pathogenesis with Chikungunya Virus Research Tools.
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Published in |
Current topics in microbiology and immunology, March 2019
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DOI | 10.1007/82_2019_158 |
Pubmed ID | |
Authors |
Carissimo, Guillaume, Ng, Lisa F P, Guillaume Carissimo, Lisa F. P. Ng |
Abstract |
Since its re-emergence in 2006, Chikungunya has been a major health concern in endemic areas. Transmitted by Aedes mosquitoes to mammalian hosts, Chikungunya leads to persistent debilitating symptoms in a high proportion of symptomatic human cases. In this review, we present several tools on the mosquito vector side as well as on the mammalian side that have been used to advance research on Chikungunya transmission and immunopathogenesis. These tools lead to key understandings of viral replication in both hosts, and innate and adaptive responses mediating virus clearance and pathology in mammals. This comprehension of viral mechanisms has allowed the development of promising treatment avenues in animal models that will need to be further explored. However, research efforts need to continue in order to develop better and unbiased tools to assess antiviral and treatment strategies as well as further understand immune mechanisms at play in human pathologies. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 20% |
Student > Master | 3 | 12% |
Researcher | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Other | 2 | 8% |
Other | 5 | 20% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 7 | 28% |
Immunology and Microbiology | 5 | 20% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Medicine and Dentistry | 2 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 1 | 4% |
Unknown | 6 | 24% |