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Understanding Molecular Pathogenesis with Chikungunya Virus Research Tools.

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Chapter title
Understanding Molecular Pathogenesis with Chikungunya Virus Research Tools.
Published in
Current topics in microbiology and immunology, March 2019
DOI 10.1007/82_2019_158
Pubmed ID
Authors

Carissimo, Guillaume, Ng, Lisa F P, Guillaume Carissimo, Lisa F. P. Ng

Abstract

Since its re-emergence in 2006, Chikungunya has been a major health concern in endemic areas. Transmitted by Aedes mosquitoes to mammalian hosts, Chikungunya leads to persistent debilitating symptoms in a high proportion of symptomatic human cases. In this review, we present several tools on the mosquito vector side as well as on the mammalian side that have been used to advance research on Chikungunya transmission and immunopathogenesis. These tools lead to key understandings of viral replication in both hosts, and innate and adaptive responses mediating virus clearance and pathology in mammals. This comprehension of viral mechanisms has allowed the development of promising treatment avenues in animal models that will need to be further explored. However, research efforts need to continue in order to develop better and unbiased tools to assess antiviral and treatment strategies as well as further understand immune mechanisms at play in human pathologies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 20%
Student > Master 3 12%
Researcher 3 12%
Student > Doctoral Student 2 8%
Other 2 8%
Other 5 20%
Unknown 5 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 28%
Immunology and Microbiology 5 20%
Biochemistry, Genetics and Molecular Biology 3 12%
Medicine and Dentistry 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 1 4%
Unknown 6 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2019.
All research outputs
#20,563,454
of 23,138,859 outputs
Outputs from Current topics in microbiology and immunology
#604
of 684 outputs
Outputs of similar age
#302,582
of 351,752 outputs
Outputs of similar age from Current topics in microbiology and immunology
#1
of 1 outputs
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