Chapter title |
Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?
|
---|---|
Chapter number | 24 |
Book title |
Parkinson’s Disease and Related Disorders
|
Published in |
Journal of neural transmission Supplementum, December 2005
|
DOI | 10.1007/978-3-211-45295-0_24 |
Pubmed ID | |
Book ISBNs |
978-3-21-128927-3, 978-3-21-145295-0
|
Authors |
Lannuzel A, Höglinger GU, Champy P, Michel PP, Hirsch EC, Ruberg M, A. Lannuzel, G. U. Höglinger, P. Champy, P. P. Michel, E. C. Hirsch, M. Ruberg, Dr. A. Lannuzel, Lannuzel, A., Höglinger, G. U., Champy, P., Michel, P. P., Hirsch, E. C., Ruberg, M. |
Abstract |
An abnormally frequent atypical levodopa-unresponsive, akinetic-rigid syndrome with some similarity to PSP was identified in the Caribbean island Guadeloupe, and was associated with the consumption of plants of the Annonacea family, especially Annona muricata (corossol, soursop) suggesting a possible toxic etiology. Annonaceae contain two groups of potential toxins, alkaloids and acetogenins. Both alkaloids and annonacin, the most abundant acetogenin, were toxic in vitro to dopaminergic and other neurons. However we have focused our work on annonacin for two reasons: (1) annonacin was toxic in nanomolar concentrations, whereas micromolar concentrations of the alkaloids were needed, (2) acetogenins are potent mitochondrial poisons, like other parkinsonism-inducing compounds. We have also shown that high concentrations of annonacin are present in the fruit or aqueous extracts of the leaves of A. muricata, can cross the blood brain barrier since it was detected in brain parenchyma of rats treated chronically with the molecule, and induced neurodegeneration of basal ganglia in these animals, similar to that observed in atypical parkinsonism. These studies reinforce the concept that consumption of Annonaceae may contribute to the pathogenesis of atypical parkinsonism in Guadeloupe. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
Unknown | 61 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 16% |
Student > Bachelor | 8 | 13% |
Researcher | 8 | 13% |
Student > Ph. D. Student | 8 | 13% |
Student > Doctoral Student | 5 | 8% |
Other | 8 | 13% |
Unknown | 15 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 23% |
Medicine and Dentistry | 10 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 13% |
Neuroscience | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 6 | 10% |
Unknown | 17 | 27% |