| Chapter title |
microRNA and Chronic Lymphocytic Leukemia
|
|---|---|
| Chapter number | 2 |
| Book title |
microRNA: Cancer
|
| Published in |
Advances in experimental medicine and biology, January 2015
|
| DOI | 10.1007/978-3-319-23730-5_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-923729-9, 978-3-31-923730-5
|
| Authors |
Giza, Dana Elena, Calin, George A., Dana Elena Giza, George A. Calin |
| Abstract |
Expression profiling of microRNAs identified important differences in microRNA expression between CLL samples and normal CD5(+) B-cells. Researchers have first discussed the dual role of miRNAs working as tumor suppressors (inhibiting malignant potential) or as oncogenes (activating malignant potential) in CLL pathogenesis. Understanding the roles of miRNAs in leukemic cells brings information on a new layer of gene regulation and also provides new markers for improved diagnosis and prognosis, as well as novel therapeutic options for CLL patients. Herein we will focus on the roles of miRNAs in CLL, highlighting what is already known about their function, proposing a novel model of CLL predisposition and progression, and describing the challenges for the near future. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 23% |
| Researcher | 4 | 18% |
| Other | 2 | 9% |
| Unspecified | 1 | 5% |
| Librarian | 1 | 5% |
| Other | 4 | 18% |
| Unknown | 5 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 23% |
| Agricultural and Biological Sciences | 4 | 18% |
| Medicine and Dentistry | 4 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Unspecified | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 6 | 27% |