| Chapter title |
Sonoporation: Applications for Cancer Therapy
|
|---|---|
| Chapter number | 15 |
| Book title |
Therapeutic Ultrasound
|
| Published in |
Advances in experimental medicine and biology, February 2016
|
| DOI | 10.1007/978-3-319-22536-4_15 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-922535-7, 978-3-31-922536-4
|
| Authors |
Jiale Qin, Tzu-Yin Wang, Jürgen K. Willmann |
| Editors |
Jean-Michel Escoffre, Ayache Bouakaz |
| Abstract |
Therapeutic efficacy of both traditional chemotherapy and gene therapy in cancer is highly dependent on the ability to deliver drugs across natural barriers, such as the vessel wall or tumor cell membranes. In this regard, sonoporation induced by ultrasound-guided microbubble (USMB) destruction has been widely investigated in the enhancement of therapeutic drug delivery given it can help overcome these natural barriers, thereby increasing drug delivery into cancer. In this chapter we discuss challenges in current cancer therapy and how some of these challenges could be overcome using USMB-mediated drug delivery. We particularly focus on recent advances in delivery approaches that have been developed to further improve therapeutic efficiency and specificity of various cancer treatments. An example of clinical translation of USMB-mediated drug delivery is also shown. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 28% |
| Researcher | 7 | 18% |
| Student > Bachelor | 3 | 8% |
| Student > Master | 3 | 8% |
| Professor | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 12 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 8 | 20% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Medicine and Dentistry | 3 | 8% |
| Physics and Astronomy | 3 | 8% |
| Other | 6 | 15% |
| Unknown | 12 | 30% |