| Chapter title |
Signatures of Natural Selection and Ecological Differentiation in Microbial Genomes
|
|---|---|
| Chapter number | 17 |
| Book title |
Ecological Genomics
|
| Published in |
Advances in experimental medicine and biology, October 2013
|
| DOI | 10.1007/978-94-007-7347-9_17 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-077346-2, 978-9-40-077347-9
|
| Authors |
B. Jesse Shapiro |
| Editors |
Christian R. Landry, Nadia Aubin-Horth |
| Abstract |
We live in a microbial world. Most of the genetic and metabolic diversity that exists on earth - and has existed for billions of years - is microbial. Making sense of this vast diversity is a daunting task, but one that can be approached systematically by analyzing microbial genome sequences. This chapter explores how the evolutionary forces of recombination and selection act to shape microbial genome sequences, leaving signatures that can be detected using comparative genomics and population-genetic tests for selection. I describe the major classes of tests, paying special attention to their relative strengths and weaknesses when applied to microbes. Specifically, I apply a suite of tests for selection to a set of closely-related bacterial genomes with different microhabitat preferences within the marine water column, shedding light on the genomic mechanisms of ecological differentiation in the wild. I will focus on the joint problem of simultaneously inferring the boundaries between microbial populations, and the selective forces operating within and between populations. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 6% |
| Unknown | 15 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 25% |
| Researcher | 3 | 19% |
| Student > Master | 2 | 13% |
| Student > Postgraduate | 2 | 13% |
| Professor > Associate Professor | 2 | 13% |
| Other | 1 | 6% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 50% |
| Biochemistry, Genetics and Molecular Biology | 3 | 19% |
| Environmental Science | 1 | 6% |
| Computer Science | 1 | 6% |
| Physics and Astronomy | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 1 | 6% |