Chapter title |
Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins
|
---|---|
Chapter number | 17 |
Book title |
Delta Opioid Receptor Pharmacology and Therapeutic Applications
|
Published in |
Handbook of experimental pharmacology, July 2016
|
DOI | 10.1007/164_2016_17 |
Pubmed ID | |
Book ISBNs |
978-3-31-995131-7, 978-3-31-995133-1
|
Authors |
Roques, Bernard P, Bernard P. Roques, Roques, Bernard P. |
Abstract |
Very few discoveries in the neurosciences have triggered clinical speculation and experimentation regarding the etiology of psychiatric illness to the same extent as that following identification of the opiate receptor(s) and subsequent isolation of endogenous morphine-like peptides. There is overwhelming evidence in animals and in human that opioids are involved in behaviorally relevant issues such as the modulation of pain, the response to stress, motivation, addiction, sexuality, food intake, etc., but our knowledge on the possible relation between opioids and mental illness is still very limited.These responses could be explored eitheir by using higlhy selective delta agonist or by emphasizing the effects of phasically secreted endogenous opioid peptides, enkephalin. Both approaches were investigated in particular through protection of enkephalin degradation by dual enkephalinase ihibitors DENKIs such as RB101, PL37 or PL265. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 15% |
Other | 2 | 10% |
Student > Bachelor | 2 | 10% |
Researcher | 2 | 10% |
Professor | 1 | 5% |
Other | 3 | 15% |
Unknown | 7 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 3 | 15% |
Medicine and Dentistry | 2 | 10% |
Neuroscience | 2 | 10% |
Sports and Recreations | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 3 | 15% |
Unknown | 7 | 35% |