| Chapter title |
Clinical Trial Design for Investigational Cardio-Regenerative Therapy
|
|---|---|
| Chapter number | 11 |
| Book title |
Cardiac Extracellular Matrix
|
| Published in |
Advances in experimental medicine and biology, September 2018
|
| DOI | 10.1007/978-3-319-97421-7_11 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-997420-0, 978-3-31-997421-7
|
| Authors |
Amish N. Raval, Raval, Amish N. |
| Abstract |
Human trials of cardio-regenerative biologic therapies are being performed worldwide to address a growing, unmet need for durable treatments of cardiovascular disease. A well-constructed clinical trial design for these novel therapies requires careful attention to defining a clear hypothesis, a patient population, and anticipated outcomes. The scope of screening, method of randomization, blinding approach, data monitoring, and statistical analysis plan are the foundational elements that must be addressed in any clinical trial. Although the experience of human trials involving extracellular matrix constructs for cardiovascular disease treatment is limited, numerous lessons have been learned in the field of cell therapy that are translatable across all biologic treatment options. Future progress in this field may include testing combinations of cells, gene-transfer agents, and matrix and identifying treatment responders versus nonresponders. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 18% |
| Student > Bachelor | 3 | 18% |
| Student > Doctoral Student | 2 | 12% |
| Student > Master | 2 | 12% |
| Unknown | 7 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 29% |
| Veterinary Science and Veterinary Medicine | 1 | 6% |
| Immunology and Microbiology | 1 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Chemistry | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 7 | 41% |