Chapter title |
Extracellular Matrix for Myocardial Repair
|
---|---|
Chapter number | 8 |
Book title |
Cardiac Extracellular Matrix
|
Published in |
Advances in experimental medicine and biology, September 2018
|
DOI | 10.1007/978-3-319-97421-7_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-997420-0, 978-3-31-997421-7
|
Authors |
Jenna L. Dziki, Stephen F. Badylak, Dziki, Jenna L., Badylak, Stephen F. |
Abstract |
Multiple strategies have been investigated to restore functional myocardium following injury or disease including the local administration of cytokines or chemokines, stem/progenitor cell therapy, mechanical circulatory support, pharmacologic use, and the use of inductive biomaterials. The use of xenogeneic biologic scaffolds composed of extracellular matrix (ECM) has been shown to facilitate functional restoration of several tissues and organs including the esophagus, skeletal muscle, skin, and myocardium, among others. The present chapter describes the current understanding of specific components of biologic scaffolds composed of ECM, the mechanisms by which ECM bioscaffolds promote constructive cardiac remodeling after injury, determinants of remodeling outcome, and the versatility of ECM as a potential cardiac therapeutic. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 54 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 22% |
Researcher | 10 | 18% |
Student > Master | 8 | 15% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 7 | 13% |
Unknown | 11 | 20% |
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Engineering | 6 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 7 | 13% |
Unknown | 15 | 27% |