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Serpins

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Cover of 'Serpins'

Table of Contents

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    Book Overview
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    Chapter 1 Overview of Serpins and Their Roles in Biological Systems
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    Chapter 2 Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography
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    Chapter 3 Serpin Phage Display: The Use of a T7 System to Probe Reactive Center Loop Libraries with Different Serine Proteinases
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    Chapter 4 Kinetic Measurement of Serpin Inhibitory Activity by Real-Time Fluorogenic Biochemical Assay
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    Chapter 5 Methods for Identifying Virus-Derived Serpins
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    Chapter 6 In Vitro Approaches for the Assessment of Serpin Polymerization
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    Chapter 7 Cellular Models for the Serpinopathies
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    Chapter 8 Binding of Serpins to Immobilized Phospholipids and Phospholipids in Suspension
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    Chapter 9 Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing
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    Chapter 10 In Vivo Analysis of Alpha-1-Antitrypsin Functions in Autoimmune Disease Models
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    Chapter 11 Analysis of In Vivo Serpin Functions in Models of Inflammatory Vascular Disease
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    Chapter 12 Gene Delivery of Alpha-1-Antitrypsin Using Recombinant Adeno-Associated Virus (rAAV)
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    Chapter 13 Serpins in Venous Thrombosis and Venous Thrombus Resolution
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    Chapter 14 Next-Generation Sequencing Library Preparation for 16S rRNA Microbiome Analysis After Serpin Treatment
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    Chapter 15 Methods for Assessing Serpins as Neuroprotective Therapeutics
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    Chapter 16 Adeno-Associated Virus Delivery of Viral Serpins for Ocular Diseases: Design and Validation
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    Chapter 17 Serpins: Development for Therapeutic Applications
Attention for Chapter 5: Methods for Identifying Virus-Derived Serpins
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Chapter title
Methods for Identifying Virus-Derived Serpins
Chapter number 5
Book title
Serpins
Published in
Methods in molecular biology, September 2018
DOI 10.1007/978-1-4939-8645-3_5
Pubmed ID
Book ISBNs
978-1-4939-8644-6, 978-1-4939-8645-3
Authors

Masmudur M. Rahman, Rahman, Masmudur M.

Abstract

The serpin family of serine proteinase inhibitors plays key roles in the maintenance of mammalian homeostasis. Virus-encoded serpins disrupt the balance of mammalian proteases to facilitate virus replication in the infected host. DNA viruses, in particular members of the poxvirus family, have acquired multiple copies of the functional serpins which are essential for viral pathogenesis. Virus-encoded serpins have proven to be very effective inhibitors of host proteases and thus are very attractive candidate molecules as immunomodulatory drugs. With this chapter we explain approaches to identifying immune-modulating viral serpins.

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Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 1 100%
Readers by discipline Count As %
Chemistry 1 100%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2018.
All research outputs
#18,649,291
of 23,103,436 outputs
Outputs from Methods in molecular biology
#7,990
of 13,208 outputs
Outputs of similar age
#258,184
of 336,306 outputs
Outputs of similar age from Methods in molecular biology
#158
of 247 outputs
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So far Altmetric has tracked 13,208 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 247 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.