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mTOR

Overview of attention for book
Cover of 'mTOR'

Table of Contents

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    Book Overview
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    Chapter 1 Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life.
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    Chapter 2 Biochemical and Pharmacological Inhibition of mTOR by Rapamycin and an ATP-Competitive mTOR Inhibitor.
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    Chapter 3 Evaluation of the Nutrient-Sensing mTOR Pathway.
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    Chapter 4 mTOR Activity Under Hypoxia.
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    Chapter 5 Isolation of the mTOR Complexes by Affinity Purification.
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    Chapter 6 An In Vitro Assay for the Kinase Activity of mTOR Complex 2
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    Chapter 7 Overexpression or Downregulation of mTOR in Mammalian Cells.
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    Chapter 8 Detection of Cytoplasmic and Nuclear Functions of mTOR by Fractionation.
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    Chapter 9 Evaluation of rapamycin-induced cell death.
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    Chapter 10 Evaluation of mTOR-Regulated mRNA Translation
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    Chapter 11 A Genome-wide RNAi Screen for Polypeptides that Alter rpS6 Phosphorylation.
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    Chapter 12 Immunohistochemical Analysis of mTOR Activity in Tissues.
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    Chapter 13 Assessing Cell Size and Cell Cycle Regulation in Cells with Altered TOR Activity.
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    Chapter 14 Quantitative Visualization of Autophagy Induction by mTOR Inhibitors.
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    Chapter 15 The In Vivo Evaluation of Active-Site TOR Inhibitors in Models of BCR-ABL+ Leukemia.
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    Chapter 16 Inducible raptor and rictor Knockout Mouse Embryonic Fibroblasts.
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    Chapter 17 Expanding Human T Regulatory Cells with the mTOR-Inhibitor Rapamycin.
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    Chapter 18 Rapamycin-induced enhancement of vaccine efficacy in mice.
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    Chapter 19 Utilizing a Retroviral RNAi System to Investigate In Vivo mTOR Functions in T Cells.
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    Chapter 20 Exploring Functional In Vivo Consequences of the Selective Genetic Ablation of mTOR Signaling in T Helper Lymphocytes.
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    Chapter 21 Evaluating the Therapeutic Potential of mTOR Inhibitors Using Mouse Genetics.
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    Chapter 22 Inhibition of PI3K-Akt-mTOR Signaling in Glioblastoma by mTORC1/2 Inhibitors.
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    Chapter 23 Assessing the Function of mTOR in Human Embryonic Stem Cells.
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    Chapter 24 Video-EEG Monitoring Methods for Characterizing Rodent Models of Tuberous Sclerosis and Epilepsy.
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    Chapter 25 A Genetic Model to Dissect the Role of Tsc-mTORC1 in Neuronal Cultures.
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    Chapter 26 Tissue-specific ablation of tsc1 in pancreatic Beta-cells.
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    Chapter 27 A Mouse Model of Diet-Induced Obesity and Insulin Resistance
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    Chapter 28 Rapamycin as immunosuppressant in murine transplantation model.
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    Chapter 29 Development of ATP-Competitive mTOR Inhibitors.
Attention for Chapter 22: Inhibition of PI3K-Akt-mTOR Signaling in Glioblastoma by mTORC1/2 Inhibitors.
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Chapter title
Inhibition of PI3K-Akt-mTOR Signaling in Glioblastoma by mTORC1/2 Inhibitors.
Chapter number 22
Book title
mTOR
Published in
Methods in molecular biology, September 2011
DOI 10.1007/978-1-61779-430-8_22
Pubmed ID
22125077
Book ISBNs
978-1-61779-429-2, 978-1-61779-430-8
Authors

Fan QW, Weiss WA, Qi-Wen Fan, William A. Weiss, Fan, Qi-Wen, Weiss, William A.

Editors

Thomas Weichhart

Abstract

Amplification of the gene encoding the epidermal growth factor receptor (EGFR) occurs commonly in glioblastoma (GBM), leading to activation of downstream kinases, including phosphatidylinositol 3'-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR). A serine-threonine kinase, mTOR controls cell growth by regulating mRNA translation, metabolism, and autophagy; acting as both a downstream effector and upstream regulator of PI3K. These signaling functions are distributed between at least two distinct complexes, mTORC1 and mTORC2 with respect to pathway specificity. We have investigated mTOR signaling in glioma cells with the allosteric mTORC1 inhibitor rapamycin, the mTORC1/2 inhibitor Ku-0063794, a dual PI3K/mTORC1/2 kinase inhibitor PI-103, and siRNA against raptor, rictor, or mTOR, and evaluated the value of mTOR inhibitors for the treatment of glioblastoma.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Brazil 1 2%
Unknown 61 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 19%
Student > Ph. D. Student 9 14%
Student > Bachelor 7 11%
Student > Master 6 10%
Other 3 5%
Other 11 17%
Unknown 15 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 25%
Medicine and Dentistry 11 17%
Biochemistry, Genetics and Molecular Biology 10 16%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Neuroscience 2 3%
Other 3 5%
Unknown 18 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2011.
All research outputs
#18,301,870
of 22,659,164 outputs
Outputs from Methods in molecular biology
#7,806
of 13,019 outputs
Outputs of similar age
#109,604
of 131,786 outputs
Outputs of similar age from Methods in molecular biology
#25
of 49 outputs
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So far Altmetric has tracked 13,019 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.

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