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mTOR

Overview of attention for book
Cover of 'mTOR'

Table of Contents

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    Book Overview
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    Chapter 1 Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life.
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    Chapter 2 Biochemical and Pharmacological Inhibition of mTOR by Rapamycin and an ATP-Competitive mTOR Inhibitor.
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    Chapter 3 Evaluation of the Nutrient-Sensing mTOR Pathway.
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    Chapter 4 mTOR Activity Under Hypoxia.
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    Chapter 5 Isolation of the mTOR Complexes by Affinity Purification.
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    Chapter 6 An In Vitro Assay for the Kinase Activity of mTOR Complex 2
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    Chapter 7 Overexpression or Downregulation of mTOR in Mammalian Cells.
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    Chapter 8 Detection of Cytoplasmic and Nuclear Functions of mTOR by Fractionation.
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    Chapter 9 Evaluation of rapamycin-induced cell death.
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    Chapter 10 Evaluation of mTOR-Regulated mRNA Translation
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    Chapter 11 A Genome-wide RNAi Screen for Polypeptides that Alter rpS6 Phosphorylation.
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    Chapter 12 Immunohistochemical Analysis of mTOR Activity in Tissues.
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    Chapter 13 Assessing Cell Size and Cell Cycle Regulation in Cells with Altered TOR Activity.
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    Chapter 14 Quantitative Visualization of Autophagy Induction by mTOR Inhibitors.
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    Chapter 15 The In Vivo Evaluation of Active-Site TOR Inhibitors in Models of BCR-ABL+ Leukemia.
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    Chapter 16 Inducible raptor and rictor Knockout Mouse Embryonic Fibroblasts.
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    Chapter 17 Expanding Human T Regulatory Cells with the mTOR-Inhibitor Rapamycin.
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    Chapter 18 Rapamycin-induced enhancement of vaccine efficacy in mice.
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    Chapter 19 Utilizing a Retroviral RNAi System to Investigate In Vivo mTOR Functions in T Cells.
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    Chapter 20 Exploring Functional In Vivo Consequences of the Selective Genetic Ablation of mTOR Signaling in T Helper Lymphocytes.
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    Chapter 21 Evaluating the Therapeutic Potential of mTOR Inhibitors Using Mouse Genetics.
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    Chapter 22 Inhibition of PI3K-Akt-mTOR Signaling in Glioblastoma by mTORC1/2 Inhibitors.
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    Chapter 23 Assessing the Function of mTOR in Human Embryonic Stem Cells.
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    Chapter 24 Video-EEG Monitoring Methods for Characterizing Rodent Models of Tuberous Sclerosis and Epilepsy.
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    Chapter 25 A Genetic Model to Dissect the Role of Tsc-mTORC1 in Neuronal Cultures.
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    Chapter 26 Tissue-specific ablation of tsc1 in pancreatic Beta-cells.
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    Chapter 27 A Mouse Model of Diet-Induced Obesity and Insulin Resistance
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    Chapter 28 Rapamycin as immunosuppressant in murine transplantation model.
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    Chapter 29 Development of ATP-Competitive mTOR Inhibitors.
Attention for Chapter 18: Rapamycin-induced enhancement of vaccine efficacy in mice.
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Citations

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Chapter title
Rapamycin-induced enhancement of vaccine efficacy in mice.
Chapter number 18
Book title
mTOR
Published in
Methods in molecular biology, September 2011
DOI 10.1007/978-1-61779-430-8_18
Pubmed ID
22125073
Book ISBNs
978-1-61779-429-2, 978-1-61779-430-8
Authors

Jagannath C, Bakhru P, Chinnaswamy Jagannath, Pearl Bakhru

Editors

Thomas Weichhart

Abstract

Th1 immunity protects against tuberculosis infection in mice and humans. The widely used BCG vaccine primes CD4 and CD8 T cells through signaling mechanisms from dendritic cells and macrophages. The latter express MHC-II and MHC-I molecules through which peptides from BCG vaccine are presented to CD4 and CD8 T cells, respectively. Since BCG sequesters within a phagosome that does not fuse with lysosomes, generation of peptides within antigen-presenting cells infected with BCG occurs with reduced efficiency. We demonstrate that activation of DCs containing BCG vaccine with rapamycin leads to an enhanced ability of DC vaccines to immunize mice against tuberculosis. Coadministration of rapamycin with BCG vaccine also enhanced Th1 immunity. We propose that rapamycin-mediated increase in Th1 responses offers novel models to study mTOR-mediated regulation of immunity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
India 1 2%
Russia 1 2%
Unknown 41 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 27%
Student > Doctoral Student 6 14%
Student > Bachelor 4 9%
Other 4 9%
Student > Ph. D. Student 4 9%
Other 7 16%
Unknown 7 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 25%
Biochemistry, Genetics and Molecular Biology 7 16%
Immunology and Microbiology 7 16%
Medicine and Dentistry 5 11%
Nursing and Health Professions 1 2%
Other 5 11%
Unknown 8 18%

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