Chapter title |
Broadband NIRS Cerebral Cytochrome-C-Oxidase Response to Anoxia Before and After Hypoxic-Ischaemic Injury in Piglets
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Chapter number | 24 |
Book title |
Oxygen Transport to Tissue XL
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Published in |
Advances in experimental medicine and biology, August 2018
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DOI | 10.1007/978-3-319-91287-5_24 |
Pubmed ID | |
Book ISBNs |
978-3-31-991285-1, 978-3-31-991287-5
|
Authors |
Gemma Bale, Ajay Rajaram, Matthew Kewin, Laura Morrison, Alan Bainbridge, Mamadou Diop, Keith St Lawrence, Ilias Tachtsidis, Bale, G, Rajaram, A, Kewin, M, Morrison, L, Bainbridge, A, Diop, M, St Lawrence, K, Tachtsidis, I, Bale, Gemma, Rajaram, Ajay, Kewin, Matthew, Morrison, Laura, Bainbridge, Alan, Diop, Mamadou, St Lawrence, Keith, Tachtsidis, Ilias |
Abstract |
Perinatal hypoxic ischaemic (HI) encephalopathy is associated with severe neurodevelopment problems and mortality. This study uses broadband continuous-wave near-infrared spectroscopy (NIRS) to assess the early changes in cerebral oxygenation and metabolism after HI injury in an animal model using controlled anoxia events. Anoxia was induced before and 1 h after various levels of HI injury to assess the metabolic response via the changes in the oxidation state of cytochrome-c-oxidase (oxCCO), a marker of oxidative metabolism. The oxCCO responses to anoxia were classified into five categories: increase, no change, decrease, biphasic and triphasic responses. The most common response (54%) was a biphasic decrease in oxCCO. A change in the classification of the metabolic response to anoxia after HI injury indicated a severe injury, as determined by proton magnetic resonance spectroscopy, with 86% sensitivity. This shows that broadband NIRS can identify disturbances to cerebral metabolism in the first hours after severe HI injury. |
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Mendeley readers
Geographical breakdown
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 15% |
Researcher | 4 | 15% |
Student > Ph. D. Student | 4 | 15% |
Professor > Associate Professor | 2 | 7% |
Student > Bachelor | 2 | 7% |
Other | 2 | 7% |
Unknown | 9 | 33% |
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Physics and Astronomy | 3 | 11% |
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Neuroscience | 2 | 7% |
Unknown | 12 | 44% |