Chapter title |
The Mitochondrial Na+/Ca2+ Exchanger is Necessary but Not Sufficient for Ca2+ Homeostasis and Viability
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Chapter number | 45 |
Book title |
Oxygen Transport to Tissue XL
|
Published in |
Advances in experimental medicine and biology, August 2018
|
DOI | 10.1007/978-3-319-91287-5_45 |
Pubmed ID | |
Book ISBNs |
978-3-31-991285-1, 978-3-31-991287-5
|
Authors |
Timon Cheng-Yi Liu, Xiao-Ming Tang, Rui Duan, Lei Ma, Ling Zhu, Quan-Guang Zhang, Liu, Timon Cheng-Yi, Tang, Xiao-Ming, Duan, Rui, Ma, Lei, Zhu, Ling, Zhang, Quan-Guang |
Abstract |
Luongo et al. found that the mitochondrial Na+/Ca2+ exchanger (NCLX) was essential for Ca2+ homeostasis and viability. Here, we re-analyze their data in terms of fractal self-similarity and quantitative difference (QD). We calculated the 7-dimension data from NCLX conditional loss-of-function mouse models, and the 9-dimension data from NCLX overexpression (NCLX-Tg) models. The 9-dimension data of the NCLX-Tg and its tTA control were partially self-similar to each other, while the 7-dimension data in NCLX knockout models were not. The NCLX may be necessary but is not sufficient for Ca2+ homeostasis and viability. |
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