Chapter title |
Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion.
|
---|---|
Chapter number | 12 |
Book title |
Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations
|
Published in |
Results and problems in cell differentiation, January 2015
|
DOI | 10.1007/978-3-319-20819-0_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-920818-3, 978-3-31-920819-0
|
Authors |
Lanning, Dennis K, Knight, Katherine L, Dennis K. Lanning, Katherine L. Knight |
Abstract |
Gene conversion, mediated by activation-induced cytidine deaminase (AID), has been found to contribute to generation of the primary antibody repertoire in several vertebrate species. Generation of the primary antibody repertoire by gene conversion of immunoglobulin (Ig) genes occurs primarily in gut-associated lymphoid tissues (GALT) and is best described in chicken and rabbit. Here, we discuss current knowledge of the mechanism of gene conversion as well as the contribution of the microbiota in promoting gene conversion of Ig genes. Finally, we propose that the antibody diversification strategy used in GALT species, such as chicken and rabbit, is conserved in a subset of human and mouse B cells. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 20% |
Unspecified | 1 | 10% |
Student > Bachelor | 1 | 10% |
Other | 1 | 10% |
Student > Master | 1 | 10% |
Other | 1 | 10% |
Unknown | 3 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 20% |
Veterinary Science and Veterinary Medicine | 1 | 10% |
Biochemistry, Genetics and Molecular Biology | 1 | 10% |
Unspecified | 1 | 10% |
Nursing and Health Professions | 1 | 10% |
Other | 1 | 10% |
Unknown | 3 | 30% |