Chapter title |
5-Aminolevulinic Acid-Protoporphyrin IX Fluorescence-Guided Surgery of High-Grade Gliomas: A Systematic Review.
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Chapter number | 3 |
Book title |
Advances and Technical Standards in Neurosurgery
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Published in |
Advances and technical standards in neurosurgery, January 2016
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DOI | 10.1007/978-3-319-21359-0_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-921358-3, 978-3-31-921359-0
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Authors |
Guyotat, Jacques, Pallud, Johan, Armoiry, Xavier, Pavlov, Vladislav, Metellus, Philippe, Jacques Guyotat, Johan Pallud, Xavier Armoiry, Vladislav Pavlov, Philippe Metellus |
Abstract |
The current first-line treatment of malignant gliomas consists in surgical resection (if possible) as large as possible. The existing tools don't permit to identify the limits of tumor infiltration, which goes beyond the zone of contrast enhancement on MRI. The fluorescence-guided malignant gliomas surgery was started 15 years ago and had become a standard of care in many countries. The technique is based on fluorescent molecule revelation using the filters, positioned within the surgical microscope. The fluorophore, protoporphyrin IX (PpIX), is converted in tumoral cells from 5-aminolevulinic acid (5-ALA), given orally before surgery. Many studies have shown that the ratio of gross total resections was higher if the fluorescence technique was used. The fluorescence signal intensity is correlated to the cell density and the PpIX concentration. The current method has a very high specificity but still lower sensibility, particularly regarding the zones with poor tumoral infiltration. This book reviews the principles of the technique and the results (extent of resection and survival). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Czechia | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 41 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 7 | 16% |
Student > Master | 7 | 16% |
Student > Doctoral Student | 6 | 14% |
Student > Bachelor | 4 | 9% |
Student > Ph. D. Student | 4 | 9% |
Other | 7 | 16% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 49% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Engineering | 3 | 7% |
Neuroscience | 2 | 5% |
Chemistry | 2 | 5% |
Other | 2 | 5% |
Unknown | 9 | 21% |