| Chapter title |
Bubble-Assisted Ultrasound: Application in Immunotherapy and Vaccination.
|
|---|---|
| Chapter number | 14 |
| Book title |
Therapeutic Ultrasound
|
| Published in |
Advances in experimental medicine and biology, January 2016
|
| DOI | 10.1007/978-3-319-22536-4_14 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-922535-7, 978-3-31-922536-4
|
| Authors |
Escoffre, Jean-Michel, Deckers, Roel, Bos, Clemens, Moonen, Chrit, Jean-Michel Escoffre, Roel Deckers, Clemens Bos, Chrit Moonen |
| Editors |
Jean-Michel Escoffre, Ayache Bouakaz |
| Abstract |
Bubble-assisted ultrasound is a versatile technology with great potential in immunotherapy and vaccination. This technology involves the exposure of immune cells (i.e., dendritic cells, lymphocytes) in-vitro or diseased tissues (i.e., brain, tumor) in-vivo to ultrasound treatment with gas bubbles. Bubble destruction leads to physical forces that induce the direct delivery of weakly permeant immuno-stimulatory molecules either into the cytoplasm of immune cells, or through the endothelial barrier of diseased tissues. Hence, therapeutic antibodies (i.e., antibody-based immunotherapy) and cytokine-encoding nucleic acids (i.e., cytokine gene therapy) can be successfully delivered into diseased tissues, thus improving immune responses. In addition, protein antigens, as well as antigen-encoding nucleic acids (pDNA, mRNA), can be delivered into dendritic cells (i.e., dendritic cell-based vaccines), thus leading to a long-lasting prophylactic or therapeutic immunization. This chapter focuses on the state-of-the-art of bubble-assisted ultrasound in the field of immunotherapy and vaccination. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 23% |
| Student > Ph. D. Student | 7 | 23% |
| Student > Master | 5 | 16% |
| Student > Bachelor | 3 | 10% |
| Student > Doctoral Student | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 5 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Medicine and Dentistry | 4 | 13% |
| Engineering | 3 | 10% |
| Physics and Astronomy | 3 | 10% |
| Other | 6 | 19% |
| Unknown | 5 | 16% |