Chapter title |
EGFR Trafficking in Physiology and Cancer
|
---|---|
Chapter number | 9 |
Book title |
Endocytosis and Signaling
|
Published in |
Progress in molecular and subcellular biology, August 2018
|
DOI | 10.1007/978-3-319-96704-2_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-996703-5, 978-3-31-996704-2
|
Authors |
Giusi Caldieri, Maria Grazia Malabarba, Pier Paolo Di Fiore, Sara Sigismund, Caldieri, Giusi, Malabarba, Maria Grazia, Di Fiore, Pier Paolo, Sigismund, Sara, Fiore, Pier Paolo |
Abstract |
Signaling from the epidermal growth factor receptor (EGFR) elicits multiple biological responses, including cell proliferation, migration, and survival. Receptor endocytosis and trafficking are critical physiological processes that control the strength, duration, diversification, and spatial restriction of EGFR signaling through multiple mechanisms, which we review in this chapter. These mechanisms include: (i) regulation of receptor density and activation at the cell surface; (ii) concentration of receptors into distinct nascent endocytic structures; (iii) commitment of the receptor to different endocytic routes; (iv) endosomal sorting and postendocytic trafficking of the receptor through distinct pathways, and (v) recycling to restricted regions of the cell surface. We also highlight how communication between organelles controls EGFR activity along the endocytic route. Finally, we illustrate how abnormal trafficking of EGFR oncogenic mutants, as well as alterations of the endocytic machinery, contributes to aberrant EGFR signaling in cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Student > Master | 8 | 15% |
Student > Bachelor | 6 | 11% |
Researcher | 5 | 9% |
Student > Doctoral Student | 3 | 6% |
Other | 6 | 11% |
Unknown | 16 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 21 | 39% |
Agricultural and Biological Sciences | 5 | 9% |
Neuroscience | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Unspecified | 1 | 2% |
Other | 2 | 4% |
Unknown | 18 | 33% |