Synthetic Biology of Cyanobacteria

Jun Ni, Fei Tao, Ping Xu, Chen Yang, Ni, Jun, Tao, Fei, Xu, Ping, Yang, Chen

Recent years have witnessed a rising demand for bioproduced chemicals owing to restricted availability of petrochemical resources and increasing environmental concerns. Extensive efforts have been invested in the metabolic engineering of microorganisms for biosynthesis of chemicals and fuels. Among these, direct conversion of CO2 to chemicals by photoautotrophic microorganism cyanobacteria represents a green route with incredibly potent. Cyanobacteria have been engineered for the production of numerous biofuels and chemicals, such as 2,3-butanediol, fatty acids, isobutyraldehyde, and n-butanol. Under the current condition, it might be initially wiser to produce chemicals with higher value or higher yield. Photosynthetic production of C3 platform chemicals could withdraw carbon close to fixation to maximize the pool of available carbon, thus achieving the strong production rates. Photosynthetic production of terpenoids is another good choice due to the higher value of these compounds. Here, we review recent advances in generating C3 chemicals and valuable terpenoids from cyanobacteria.