Chapter title |
DNA Repair and Chromosomal Translocations
|
---|---|
Chapter number | 1 |
Book title |
Chromosomal Instability in Cancer Cells
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, September 2015
|
DOI | 10.1007/978-3-319-20291-4_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-920290-7, 978-3-31-920291-4
|
Authors |
Bohlander, Stefan K., Kakadia, Purvi M., Stefan K. Bohlander, Purvi M. Kakadia |
Editors |
B. Michael Ghadimi, Thomas Ried |
Abstract |
The balance between DNA damage, especially double strand breaks, and DNA damage repair is a critical determinant of chromosomal translocation frequency. The non-homologous end-joining repair (NHEJ) pathways seem to play the major role in the generation of chromosomal translocations. The "landscape" of chromosomal translocation identified in malignancies is largely due to selection processes which operate on the growth advantages conveyed to the cells by the functional consequences of chromosomal translocations (i.e., oncogenic fusion proteins and overexpression of oncogenes, both compromising tumor suppressor gene functions). Newer studies have shown that there is an abundance of local rearrangements in many tumors, like small deletions and inversions. A better understanding of the interplay between DNA repair mechanisms and the generation of tumorigenic translocations will, among many other things, depend on an improved understanding of DNA repair mechanisms and their interplay with chromatin and the 3D organization of the interphase nucleus. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 24% |
Researcher | 3 | 14% |
Professor | 2 | 10% |
Unspecified | 1 | 5% |
Student > Bachelor | 1 | 5% |
Other | 2 | 10% |
Unknown | 7 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 29% |
Agricultural and Biological Sciences | 4 | 19% |
Medicine and Dentistry | 3 | 14% |
Unspecified | 1 | 5% |
Unknown | 7 | 33% |