| Chapter title |
Patterns of Chromosomal Aberrations in Solid Tumors.
|
|---|---|
| Chapter number | 6 |
| Book title |
Chromosomal Instability in Cancer Cells
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2015
|
| DOI | 10.1007/978-3-319-20291-4_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-920290-7, 978-3-31-920291-4
|
| Authors |
Grade, Marian, Difilippantonio, Michael J, Camps, Jordi, Marian Grade, Michael J. Difilippantonio, Jordi Camps, Difilippantonio, Michael J. |
| Abstract |
Chromosomal abnormalities are a defining feature of solid tumors. Such cytogenetic alterations are mainly classified into structural chromosomal aberrations and copy number alterations, giving rise to aneuploid karyotypes. The increasing detection of these genetic changes allowed the description of specific tumor entities and the associated patterns of gene expression. In fact, tumor-specific landscapes of gross genomic copy number changes, including aneuploidies of entire chromosome arms and chromosomes result in a global deregulation of the transcriptome of cancer cells. Furthermore, the molecular characterization of cytogenetic abnormalities has provided insights into the mechanisms of tumorigenesis and has, in a few instances, led to the clinical implementation of effective diagnostic and prognostic tools, as well as treatment strategies that target a specific genetic abnormality. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 22% |
| Student > Bachelor | 12 | 19% |
| Student > Master | 7 | 11% |
| Researcher | 5 | 8% |
| Student > Doctoral Student | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 16 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 28% |
| Agricultural and Biological Sciences | 12 | 19% |
| Medicine and Dentistry | 6 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Business, Management and Accounting | 1 | 2% |
| Other | 6 | 9% |
| Unknown | 19 | 30% |