Chapter title |
Causes of Chromosomal Instability.
|
---|---|
Chapter number | 5 |
Book title |
Chromosomal Instability in Cancer Cells
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2015
|
DOI | 10.1007/978-3-319-20291-4_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-920290-7, 978-3-31-920291-4
|
Authors |
Bastians, Holger, Holger Bastians |
Abstract |
The majority of human cancer cells are highly aneuploid harboring chromosome numbers deviating from the modal number of 46. In cancer, aneuploidy is a consequence of an increased rate of whole chromosome missegregation during mitosis, a process known as chromosomal instability (CIN). In fact, CIN is a hallmark of human cancer and is thought to contribute to tumorigenesis, tumor progression, and the development of therapy resistance by providing a high genetic variability that might foster rapid adaptation processes. However, the molecular mechanisms that cause chromosome missegregation in cancer cells are still poorly understood. So far, several mechanisms underlying CIN have been proposed and some of them are indeed detectable in human cancer cells exhibiting CIN. Examples include, for instance, weakened spindle checkpoint signaling, supernumerary centrosomes, defects in chromatid cohesion, abnormal kinetochore-microtubule attachments and increased spindle microtubule dynamics. Here, the mechanisms leading to CIN in human cancer cells are summarized. |
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United Kingdom | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 74 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 22 | 30% |
Researcher | 13 | 18% |
Student > Bachelor | 8 | 11% |
Professor > Associate Professor | 6 | 8% |
Student > Master | 5 | 7% |
Other | 8 | 11% |
Unknown | 12 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 22% |
Medicine and Dentistry | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Unspecified | 1 | 1% |
Other | 2 | 3% |
Unknown | 15 | 20% |