Chapter title |
PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)
|
---|---|
Chapter number | 484 |
Book title |
B Cell Receptor Signaling
|
Published in |
Current topics in microbiology and immunology, September 2015
|
DOI | 10.1007/82_2015_484 |
Pubmed ID | |
Book ISBNs |
978-3-31-926131-7, 978-3-31-926133-1
|
Authors |
Okkenhaug, Klaus, Burger, Jan A, Burger, Jan A., Klaus Okkenhaug, Jan A. Burger |
Abstract |
B cells provide immunity to extracellular pathogens by secreting a diverse repertoire of antibodies with high affinity and specificity for exposed antigens. The B cell receptor (BCR ) is a transmembrane antibody, which facilitates the clonal selection of B cells producing secreted antibodies of the same specificity. The diverse antibody repertoire is generated by V(D)J recombination of heavy and light chain genes, whereas affinity maturation is mediated by activation-induced cytidine deaminase (AID)-mediated mutagenesis. These processes, which are essential for the generation of adaptive humoral immunity, also render B cells susceptible to chromosomal rearrangements and point mutations that in some cases lead to cancer. In this chapter, we will review the central role of PI3K s in mediating signals from the B cell receptor that not only facilitate the development of functional B cell repertoire, but also support the growth and survival of neoplastic B cells, focusing on chronic lymphocytic leukemia (CLL ) B cells. Perhaps because of the central role played by PI3K in BCR signaling, B cell leukemia and lymphomas are the first diseases for which a PI3K inhibitor has been approved for clinical use. |
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