Chapter title |
Pig Model of Increased Cardiac Afterload Induced by Ascending Aortic Banding
|
---|---|
Chapter number | 26 |
Book title |
Experimental Models of Cardiovascular Diseases
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-8597-5_26 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8596-8, 978-1-4939-8597-5
|
Authors |
Olympia Bikou, Satoshi Miyashita, Kiyotake Ishikawa, Bikou, Olympia, Miyashita, Satoshi, Ishikawa, Kiyotake |
Abstract |
Increase in cardiac afterload as represented by hypertension is an established risk factor for cardiovascular diseases. Animal models of increased cardiac afterload offer studies aiming at identifying key molecular mechanisms and developing new therapeutic approaches. We have reported that banding of the ascending aorta in pigs results in significant cardiac hypertrophy and increased myocardial fibrosis at the chronic stages. These changes were accompanied by increased stiffness of the heart, but not by systolic dysfunction. In this chapter, we describe methods to surgically band the ascending aorta in pigs. After 3 months, animals develop systolic left ventricular pressure of >200 mmHg with above described changes in the heart. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 33% |
Student > Bachelor | 2 | 17% |
Student > Doctoral Student | 2 | 17% |
Researcher | 1 | 8% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 3 | 25% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Nursing and Health Professions | 1 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Other | 3 | 25% |
Unknown | 2 | 17% |