| Chapter title |
Badimon Perfusion Chamber: An Ex Vivo Model of Thrombosis
|
|---|---|
| Chapter number | 12 |
| Book title |
Experimental Models of Cardiovascular Diseases
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-8597-5_12 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-8596-8, 978-1-4939-8597-5
|
| Authors |
M. Urooj Zafar, Carlos G. Santos-Gallego, Lina Badimon, Juan J. Badimon, Zafar, M. Urooj, Santos-Gallego, Carlos G., Badimon, Lina, Badimon, Juan J. |
| Abstract |
The Badimon perfusion chamber is an ex vivo model of thrombosis that assesses the thrombogenicity of blood in humans and large animals. It works with native blood thereby excluding any interfering effects of anticoagulants unavoidable with the majority of platelet function testing methodologies. Each variable of the Virchow's triad (blood, blood flow, and endothelial wall) that modulates blood-vessel wall interaction and thrombus formation is incorporated in this perfusion model. These features make this device a valuable tool for the assessment of thrombogenic potential of various diseases and also gauging the efficacy of antithrombotic (anticoagulant and antiplatelet) treatments. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 43% |
| Unspecified | 1 | 14% |
| Professor | 1 | 14% |
| Student > Bachelor | 1 | 14% |
| Unknown | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 57% |
| Agricultural and Biological Sciences | 1 | 14% |
| Unspecified | 1 | 14% |
| Unknown | 1 | 14% |