Chapter title |
Development and Multiparametric Evaluation of Experimental Atherosclerosis in Rabbits
|
---|---|
Chapter number | 30 |
Book title |
Experimental Models of Cardiovascular Diseases
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-8597-5_30 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8596-8, 978-1-4939-8597-5
|
Authors |
Max L. Senders, Mark E. Lobatto, Raphael Soler, Olivier Lairez, Carlos Pérez-Medina, Claudia Calcagno, Zahi A. Fayad, Willem J. M. Mulder, Francois Fay, Senders, Max L., Lobatto, Mark E., Soler, Raphael, Lairez, Olivier, Pérez-Medina, Carlos, Calcagno, Claudia, Fayad, Zahi A., Mulder, Willem J. M., Fay, Francois |
Abstract |
Several animal models have been developed to study atherosclerosis. Here we present a rabbit atherosclerosis model generated by surgical denudation of the aortic endothelium in combination with a high-fat and cholesterol-enriched diet. This model is characterized by the formation of vascular lesions that exhibit several hallmarks of human atherosclerosis. Due to the rabbit's relative large size, as compared to rodents, this model is suited for the imaging-guided evaluation of novel therapeutic strategies using clinical scanners. In this chapter, we present an extensive outline of the procedures to induce aortic atherosclerotic lesions in rabbits as well as methods to evaluate the disease, including noninvasive in vivo multiparametric imaging and histopathology. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 22% |
Researcher | 1 | 11% |
Other | 1 | 11% |
Lecturer > Senior Lecturer | 1 | 11% |
Unknown | 4 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 2 | 22% |
Materials Science | 1 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
Unknown | 5 | 56% |