Chapter title |
Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions.
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Chapter number | 11 |
Book title |
Immune Responses to Biosurfaces
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Published in |
Advances in experimental medicine and biology, January 2015
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DOI | 10.1007/978-3-319-18603-0_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-918602-3, 978-3-31-918603-0
|
Authors |
Kourtzelis, Ioannis, Magnusson, Peetra U, Kotlabova, Klara, Lambris, John D, Chavakis, Triantafyllos, Ioannis Kourtzelis, Peetra U. Magnusson, Klara Kotlabova, John D. Lambris, Triantafyllos Chavakis, Magnusson, Peetra U., Lambris, John D. |
Abstract |
Xeno-transplantation of pancreatic islets represents a promising therapeutic alternative for the treatment of type 1 diabetes mellitus. However, potent innate immune responses induced shortly after the transplantation of donor islets to the recipient, comprising the Instant Blood Mediated Immune Reaction (IBMIR), exert detrimental actions on islet graft function. The coagulation and complement cascades together with the leukocyte and platelet populations are the major players in IBMIR. This innate immune attack affects dramatically islet integrity and leads to significant loss of function of the xenograft. In the present review, we focus on the mechanisms contributing to IBMIR components and address therapeutic intervention approaches to limit IBMIR by administering inhibitors in circulation, by coating the islet surface with inhibitors or by generating transgenic donor animals; these approaches could result in improved xenograft survival. |
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Members of the public | 1 | 100% |
Mendeley readers
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Student > Ph. D. Student | 6 | 18% |
Student > Doctoral Student | 4 | 12% |
Student > Bachelor | 4 | 12% |
Student > Master | 3 | 9% |
Researcher | 2 | 6% |
Other | 2 | 6% |
Unknown | 12 | 36% |
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Engineering | 3 | 9% |
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Immunology and Microbiology | 1 | 3% |
Other | 3 | 9% |
Unknown | 12 | 36% |