| Chapter title |
Dynamics of Double-Strand Breaks: Implications for the Formation of Chromosome Translocations
|
|---|---|
| Chapter number | 3 |
| Book title |
Chromosome Translocation
|
| Published in |
Advances in experimental medicine and biology, January 2018
|
| DOI | 10.1007/978-981-13-0593-1_3 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-130592-4, 978-9-81-130593-1
|
| Authors |
Henrike Johanna Gothe, Vera Minneker, Vassilis Roukos, Gothe, Henrike Johanna, Minneker, Vera, Roukos, Vassilis |
| Abstract |
Illegitimate joining of chromosome breaks can lead to the formation of chromosome translocations, a catastrophic type of genome rearrangements that often plays key roles in tumorigenesis. Emerging evidence suggests that the mobility of broken DNA loci can be an important determinant in partner search and clustering of individual breaks, events that can influence translocation frequency. We summarize here the recent literature on the mechanisms that regulate chromatin movement, focusing on studies exploring the motion properties of double-strand breaks in the context of chromatin, the functional consequences for DNA repair, and the formation of chromosome fusions. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 21% |
| Student > Ph. D. Student | 2 | 14% |
| Student > Master | 2 | 14% |
| Other | 1 | 7% |
| Professor > Associate Professor | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 4 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 36% |
| Agricultural and Biological Sciences | 2 | 14% |
| Nursing and Health Professions | 1 | 7% |
| Immunology and Microbiology | 1 | 7% |
| Medicine and Dentistry | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 4 | 29% |