Chapter title |
Drosophila As a Cancer Model
|
---|---|
Chapter number | 10 |
Book title |
Drosophila Models for Human Diseases
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-13-0529-0_10 |
Pubmed ID | |
Book ISBNs |
978-9-81-130528-3, 978-9-81-130529-0
|
Authors |
Masato Enomoto, Carmen Siow, Tatsushi Igaki, Enomoto, Masato, Siow, Carmen, Igaki, Tatsushi |
Abstract |
Over the last few decades, Drosophila cancer models have made great contributions to our understanding toward fundamental cancer processes. Particularly, the development of genetic mosaic technique in Drosophila has enabled us to recapitulate basic aspects of human cancers, including clonal evolution, tumor microenvironment, cancer cachexia, and anticancer drug resistance. The mosaic technique has also led to the discovery of important tumor-suppressor pathways such as the Hippo pathway and the elucidation of the mechanisms underlying tumor growth and metastasis via regulation of cell polarity, cell-cell cooperation, and cell competition. Recent approaches toward identification of novel therapeutics using fly cancer models have further proved Drosophila as a robust system with great potentials for cancer research as well as anti-cancer therapy. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 21% |
Researcher | 9 | 16% |
Student > Ph. D. Student | 9 | 16% |
Student > Doctoral Student | 4 | 7% |
Student > Bachelor | 3 | 5% |
Other | 4 | 7% |
Unknown | 16 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 35% |
Agricultural and Biological Sciences | 8 | 14% |
Neuroscience | 3 | 5% |
Nursing and Health Professions | 1 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 9% |
Unknown | 19 | 33% |