Chapter title |
Molecular inversion probe assay.
|
---|---|
Chapter number | 20 |
Book title |
Comparative Genomics
|
Published in |
Methods in molecular biology, January 2007
|
DOI | 10.1007/978-1-59745-515-2_20 |
Pubmed ID | |
Book ISBNs |
978-1-934115-37-4, 978-1-59745-515-2
|
Authors |
Nicholas H. Bergman, Farnaz Absalan, Mostafa Ronaghi |
Abstract |
We have described molecular inversion probe technologies for large-scale genetic analyses. This technique provides a comprehensive and powerful tool for the analysis of genetic variation and enables affordable, large-scale studies that will help uncover the genetic basis of complex disease and explain the individual variation in response to therapeutics. Major applications of the molecular inversion probes (MIP) technologies include targeted genotyping from focused regions to whole-genome studies, and allele quantification of genomic rearrangements. The MIP technology (used in the HapMap project) provides an efficient, scalable, and affordable way to score polymorphisms in case/control populations for genetic studies. The MIP technology provides the highest commercially available multiplexing levels and assay conversion rates for targeted genotyping. This enables more informative, genome-wide studies with either the functional (direct detection) approach or the indirect detection approach. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 15% |
Unknown | 23 | 85% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 33% |
Student > Ph. D. Student | 7 | 26% |
Other | 4 | 15% |
Student > Doctoral Student | 2 | 7% |
Student > Bachelor | 2 | 7% |
Other | 0 | 0% |
Unknown | 3 | 11% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 6 | 22% |
Medicine and Dentistry | 3 | 11% |
Chemistry | 2 | 7% |
Environmental Science | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 19% |