Chapter title |
Successful Pregnancy in a Young Woman with Multiple Acyl-CoA Dehydrogenase Deficiency
|
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Chapter number | 38 |
Book title |
JIMD Reports, Volume 39
|
Published in |
JIMD Reports, January 2017
|
DOI | 10.1007/8904_2017_38 |
Pubmed ID | |
Book ISBNs |
978-3-66-257576-5, 978-3-66-257577-2
|
Authors |
Annalisa Creanza, Mariella Cotugno, Cristina Mazzaccara, Giulia Frisso, Giancarlo Parenti, Brunella Capaldo, Creanza, Annalisa, Cotugno, Mariella, Mazzaccara, Cristina, Frisso, Giulia, Parenti, Giancarlo, Capaldo, Brunella |
Abstract |
Multiple acyl-CoA dehydrogenation deficiency (MADD) is an inborn disorder of fatty acid oxidation due to a defect in electron transfer to the respiratory chain. We describe the medical/nutritional management of a successful pregnancy in a 19-year-old woman with a known diagnosis of MADD. A high-carbohydrate, low-fat, six-meal diet supplemented with protein was prescribed to meet the nutritional needs during pregnancy. L-Carnitine supplementation was also progressively increased over the weeks. Serum acyl-carnitine profile revealed raised levels of chain-length C6-C14, which remained substantially unchanged during pregnancy. Serum amino acid profile was in the normal range indicating an adequate nutritional support. Pregnancy progressed uneventful and the patient gave birth to a healthy boy without any complication.A careful clinical monitoring associated with an adequate medical/nutritional management may improve pregnancy outcome in women with MADD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 2 | 25% |
Professor | 1 | 13% |
Student > Ph. D. Student | 1 | 13% |
Student > Doctoral Student | 1 | 13% |
Unknown | 3 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 13% |
Medicine and Dentistry | 1 | 13% |
Engineering | 1 | 13% |
Unknown | 4 | 50% |