| Chapter title |
Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?
|
|---|---|
| Chapter number | 17 |
| Book title |
Issues in Clinical Epileptology: A View from the Bench
|
| Published in |
Advances in experimental medicine and biology, January 2014
|
| DOI | 10.1007/978-94-017-8914-1_17 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-178913-4, 978-9-40-178914-1
|
| Authors |
Kim L. Powell, Katarzyna Lukasiuk, Terence J. O’Brien, Asla Pitkänen, Powell, Kim L., Lukasiuk, Katarzyna, O’Brien, Terence J., Pitkänen, Asla |
| Abstract |
Neuronal voltage-gated ion channels and ligand-gated synaptic receptors play a critical role in maintaining the delicate balance between neuronal excitation and inhibition within neuronal networks in the brain. Changes in expression of voltage-gated ion channels, in particular sodium, hyperpolarization-activated cyclic nucleotide-gated (HCN) and calcium channels, and ligand-gated synaptic receptors, in particular GABA and glutamate receptors, have been reported in many types of both genetic and acquired epilepsies, in animal models and in humans. In this chapter we review these and discuss the potential pathogenic role they may play in the epilepsies. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 33% |
| Professor | 3 | 17% |
| Professor > Associate Professor | 2 | 11% |
| Student > Master | 2 | 11% |
| Lecturer | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 4 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 4 | 22% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Agricultural and Biological Sciences | 2 | 11% |
| Neuroscience | 2 | 11% |
| Medicine and Dentistry | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 6 | 33% |