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Antibody Engineering

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Cover of 'Antibody Engineering'

Table of Contents

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    Book Overview
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    Chapter 1 Use of IMGT ® Databases and Tools for Antibody Engineering and Humanization
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    Chapter 2 Computer-Assisted Modeling of Antibody Variable Domains
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    Chapter 3 Cloning Single-Chain Antibody Fragments (ScFv) from Hyrbidoma Cells
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    Chapter 4 Human In-Cell scFv Library from Infiltrating B Cell
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    Chapter 5 Construction of Human Naive Antibody Gene Libraries
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    Chapter 6 Synthetic Customized scFv Libraries
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    Chapter 7 Selection of Stable scFv Antibodies by Phage Display
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    Chapter 8 Generation of Single Domain Antibody Fragments Derived from Camelids and Generation of Manifold Constructs
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    Chapter 9 Generation and Isolation of Target-Specific Single-Domain Antibodies from Shark Immune Repertoires
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    Chapter 10 Generation of Human Single Domain Antibody Repertoires by Kunkel Mutagenesis
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    Chapter 11 Phage Display and Selections on Purified Antigens
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    Chapter 12 Phage Display and Selections on Cells
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    Chapter 13 Humanization by CDR Grafting and Specificity-Determining Residue Grafting
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    Chapter 14 Humanization by Guided Selections
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    Chapter 15 Selection of Antibody Fragments by Yeast Display
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    Chapter 16 Evolution of Antibodies In Vitro by Ribosome Display
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    Chapter 17 Mammalian Cell Surface Display of Full Length IgG
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    Chapter 18 Production of Antibody Fragments in Escherichia coli
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    Chapter 19 Production of Antibody Derivatives in the Methylotrophic Yeast Pichia pastoris
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    Chapter 20 Monoclonal Antibody Expression in Mammalian Cells
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    Chapter 21 Production of Recombinant Antibodies in Drosophila melanogaster S2 Cells
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    Chapter 22 Production of Antibody Fragments Using the Baculovirus–Insect Cell System
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    Chapter 23 Transient and Stable Expression of Antibodies in Nicotiana Species
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    Chapter 24 Measuring Antibody–Antigen Binding Kinetics Using Surface Plasmon Resonance
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    Chapter 25 Affinity Determination of Biotinylated Antibodies by Flow Cytometry
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    Chapter 26 Affinity Maturation of Antibodies: Optimized Methods to Generate High-Quality ScFv Libraries and Isolate IgG Candidates by High-Throughput Screening
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    Chapter 27 Affinity Maturation by Semi -rational Approaches
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    Chapter 28 Molecular Scanning: Combining Random Mutagenesis, Ribosome Display, and Bioinformatic Analysis for Protein Engineering
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    Chapter 29 Fucose-Targeted Glycoengineering of Pharmaceutical Cell Lines
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    Chapter 30 Fc Engineering: Design, Expression, and Functional Characterization of Antibody Variants with Improved Effector Function
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    Chapter 31 Fc Engineering: Serum Half-Life Modulation Through FcRn Binding
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    Chapter 32 Monoclonal Antibody Lead Characterization: In Vitro and In Vivo Methods
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    Chapter 33 Production, Purification, and Characterization of scFv TNF Ligand Fusion Proteins
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    Chapter 34 Antibody-IL2 Fusion Proteins for Tumor Targeting
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    Chapter 35 Recombinant Immunotoxins with Low Endotoxins for Clinical and Animal Studies
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    Chapter 36 Chimeric Antigen Receptors for T-Cell Based Therapy
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    Chapter 37 Selection and Use of Intracellular Antibodies (Intrabodies)
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    Chapter 38 Radiolabeled Antibodies for Cancer Imaging and Therapy
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    Chapter 39 Design and Production of Multimeric Antibody Fragments, Focused on Diabodies with Enhanced Clinical Efficacy
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    Chapter 40 Production of Bispecific Antibodies: Diabodies and Tandem scFv
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Title
Antibody Engineering
Published by
Humana Press, August 2012
DOI 10.1007/978-1-61779-974-7
ISBNs
978-1-61779-973-0, 978-1-61779-974-7
Editors

Chames, Patrick

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 15%
Student > Ph. D. Student 5 15%
Researcher 5 15%
Student > Master 3 9%
Other 2 6%
Other 4 12%
Unknown 9 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 30%
Agricultural and Biological Sciences 4 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Arts and Humanities 1 3%
Chemical Engineering 1 3%
Other 4 12%
Unknown 11 33%