Attention for Chapter 47:
A Synonymous Mutation at Bovine Alpha Vitronectin Domain of Integrin Host Receptor (ITGAV) Gene Effect the Susceptibility of Foot-and-Mouth Disease in Crossbred Cattle
A Synonymous Mutation at Bovine Alpha Vitronectin Domain of Integrin Host Receptor (ITGAV) Gene Effect the Susceptibility of Foot-and-Mouth Disease in Crossbred Cattle
Chapter number
47
Book title
Advances in Microbiology, Infectious Diseases and Public Health
Published in
Advances in experimental medicine and biology, January 2017
Rani Singh, Rani Alex, Umesh Singh, Sushil Kumar, Gyanendra Singh Sengar, T. V. Raja, R. R. Alyethodi, Ashish Kumar, Rajib Deb, Singh, Rani, Alex, Rani, Singh, Umesh, Kumar, Sushil, Sengar, Gyanendra Singh, Raja, T. V., Alyethodi, R. R., Kumar, Ashish, Deb, Rajib
Abstract
Integrins are one of the major biologically active proteins responsible for Foot-and-mouth disease virus (FMDV)- host interaction. Out of various heterodimeric integrins discovered, αVβ6 heterodimer serves as the chief receptor for FMDV host tropism. Earlier studies reported that, SNPs at beta 6 subunit (ITGB6) were associated with the occurrence of the diseases in cattle. In this study we report the association between a synonymous SNP (rs719257875) at bovine alpha vitronectin domain of integrin receptor (ITGAV) gene and FMD susceptibility in cattle. A strong significant association (P < 0.0001) of the genotypes with FMD susceptibility were obtained, where the CC genotypes play a major role in occurrence of FMD in crossbred cattle.
