Chapter title |
Immune Response Against S almonella Enteritidis Is Unsettled by HIV Infection
|
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Chapter number | 40 |
Book title |
Advances in Microbiology, Infectious Diseases and Public Health
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/5584_2017_40 |
Pubmed ID | |
Book ISBNs |
978-3-31-979016-9, 978-3-31-979017-6
|
Authors |
Maira Costa Cacemiro, Milena Sobral Espíndola, Leonardo Judson Galvão-Lima, Luana Silva Soares, Caroline Fontanari, Marco Aurélio Prata, Fábio Campioni, Juliana Pfrimer Falcão, Valdes Roberto Bollela, Fabiani Gai Frantz, Cacemiro, Maira Costa, Espíndola, Milena Sobral, Galvão-Lima, Leonardo Judson, Soares, Luana Silva, Fontanari, Caroline, Prata, Marco Aurélio, Campioni, Fábio, Falcão, Juliana Pfrimer, Bollela, Valdes Roberto, Frantz, Fabiani Gai |
Abstract |
The human immunodeficiency virus (HIV) is responsible for more than 2 million new infections per year and opportunistic infections such as Salmonella spp. Gastroenteritis is an important cause of mortality and morbidity in developing countries. Monocytes and macrophages play a critical role in the innate immune response against bacterial infections. However during HIV infection the virus can infect these cells and although they are more resistant to the cytopathic effects, they represent an important viral reservoir in these patients. Our aim was to evaluate the monocyte functions from HIV-1 infected patients after in vitro exposition to Salmonella Enteritidis. Our results suggest impairment of monocytes phagocytic and microbicidal activity in HIV-1 non-treated patients, which was more evident in women, if compared with men. Moreover, monocytes from HIV-1 infected and non-treated patients after stimulation with the bacteria, produced more pro-inflammatory cytokines than monocytes from HIV-treated patients, suggesting that HIV-1 infected patients have their functions unbalanced, once in the presence of an opportunistic infection in vitro. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 2 | 13% |
Researcher | 2 | 13% |
Professor > Associate Professor | 2 | 13% |
Lecturer | 1 | 7% |
Student > Master | 1 | 7% |
Other | 3 | 20% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 6 | 40% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Nursing and Health Professions | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Unknown | 5 | 33% |