Chapter title |
Trends in Modern Drug Discovery
|
---|---|
Chapter number | 20 |
Book title |
New Approaches to Drug Discovery
|
Published in |
Handbook of experimental pharmacology, January 2015
|
DOI | 10.1007/164_2015_20 |
Pubmed ID | |
Book ISBNs |
978-3-31-928912-0, 978-3-31-928914-4
|
Authors |
Jörg Eder, Paul L. Herrling, Eder, Jörg, Herrling, Paul L. |
Abstract |
Drugs discovered by the pharmaceutical industry over the past 100 years have dramatically changed the practice of medicine and impacted on many aspects of our culture. For many years, drug discovery was a target- and mechanism-agnostic approach that was based on ethnobotanical knowledge often fueled by serendipity. With the advent of modern molecular biology methods and based on knowledge of the human genome, drug discovery has now largely changed into a hypothesis-driven target-based approach, a development which was paralleled by significant environmental changes in the pharmaceutical industry. Laboratories became increasingly computerized and automated, and geographically dispersed research sites are now more and more clustered into large centers to capture technological and biological synergies. Today, academia, the regulatory agencies, and the pharmaceutical industry all contribute to drug discovery, and, in order to translate the basic science into new medical treatments for unmet medical needs, pharmaceutical companies have to have a critical mass of excellent scientists working in many therapeutic fields, disciplines, and technologies. The imperative for the pharmaceutical industry to discover breakthrough medicines is matched by the increasing numbers of first-in-class drugs approved in recent years and reflects the impact of modern drug discovery approaches, technologies, and genomics. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 1% |
Unknown | 85 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 15% |
Student > Bachelor | 13 | 15% |
Student > Ph. D. Student | 10 | 12% |
Researcher | 6 | 7% |
Student > Doctoral Student | 5 | 6% |
Other | 13 | 15% |
Unknown | 26 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 15% |
Chemistry | 13 | 15% |
Agricultural and Biological Sciences | 7 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 8% |
Medicine and Dentistry | 5 | 6% |
Other | 13 | 15% |
Unknown | 28 | 33% |