Chapter title |
Combinatorial Optimization Models for Finding Genetic Signatures from Gene Expression Datasets
|
---|---|
Chapter number | 19 |
Book title |
Bioinformatics
|
Published in |
Methods in molecular biology, January 2008
|
DOI | 10.1007/978-1-60327-429-6_19 |
Pubmed ID | |
Book ISBNs |
978-1-60327-428-9, 978-1-60327-429-6
|
Authors |
Regina Berretta, Wagner Costa, Pablo Moscato, Berretta, Regina, Costa, Wagner, Moscato, Pablo |
Abstract |
The aim of this chapter is to present combinatorial optimization models and techniques for the analysis of microarray datasets. The chapter illustrates the application of a novel objective function that guides the search for high-quality solutions for sequential ordering of expression profiles. The approach is unsupervised and a metaheuristic method (a memetic algorithm) is used to provide high-quality solutions. For the problem of selecting discriminative groups of genes, we used a supervised method that has provided good results in a variety of datasets. This chapter illustrates the application of these models in an Alzheimer's disease microarray dataset. |
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