Chapter title |
Vector-mediated antibody gene transfer for infectious diseases.
|
---|---|
Chapter number | 8 |
Book title |
Gene Therapy for HIV and Chronic Infections
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-1-4939-2432-5_8 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2431-8, 978-1-4939-2432-5
|
Authors |
Bruce C Schnepp, Philip R Johnson, Bruce C. Schnepp, Philip R. Johnson |
Abstract |
This chapter discusses the emerging field of vector-mediated antibody gene transfer as an alternative vaccine for infectious disease, with a specific focus on HIV. However, this methodology need not be confined to HIV-1; the general strategy of vector-mediated antibody gene transfer can be applied to other difficult vaccine targets like hepatitis C virus, malaria, respiratory syncytial virus, and tuberculosis. This approach is an improvement over classical passive immunization strategies that administer antibody proteins to the host to provide protection from infection. With vector-mediated gene transfer, the antibody gene is delivered to the host, via a recombinant adeno-associated virus (rAAV) vector; this in turn results in long-term endogenous antibody expression from the injected muscle that confers protective immunity. Vector-mediated antibody gene transfer can rapidly move existing, potent broadly cross-neutralizing HIV-1-specific antibodies into the clinic. The gene transfer products demonstrate a potency and breadth identical to the original product. This strategy eliminates the need for immunogen design and interaction with the adaptive immune system to generate protection, a strategy that so far has shown limited promise. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
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Student > Bachelor | 7 | 22% |
Researcher | 5 | 16% |
Student > Master | 5 | 16% |
Other | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 3 | 9% |
Unknown | 8 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 19% |
Biochemistry, Genetics and Molecular Biology | 5 | 16% |
Immunology and Microbiology | 3 | 9% |
Agricultural and Biological Sciences | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 5 | 16% |
Unknown | 10 | 31% |