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Drug Discovery and Evaluation: Pharmacological Assays

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Cover of 'Drug Discovery and Evaluation: Pharmacological Assays'

Table of Contents

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    Book Overview
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    Chapter 1 α- and β-Adrenoceptor Binding
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    Chapter 2 Studies in Isolated Organs
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    Chapter 3 Cardiovascular Analysis In Vivo
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    Chapter 4 Methods to Induce Experimental Hypertension
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    Chapter 5 Coronary Drugs
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    Chapter 6 Calcium Uptake Inhibition Activity
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    Chapter 7 Antiarrhythmic Activity
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    Chapter 8 Methods to Induce Cardiac Hypertrophy and Insufficiency
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    Chapter 9 Positive Inotropic Activity (Cardiac Glycosides) Positive inotropic activity Cardiac glycosides
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    Chapter 10 Effects on Blood Supply and on Arterial and Venous Tonus
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    Chapter 11 In Vitro and Ex Vivo Tests of Coagulation and Platelet Function
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    Chapter 12 In Vitro Models of Thrombosis
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    Chapter 13 In Vivo or Ex Vivo Models for Testing Thrombosis and Hemostasis
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    Chapter 14 Hemostasis Models: Bleeding Models
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    Chapter 15 Genetic Models of Hemostasis and Thrombosis
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    Chapter 16 Critical Issues in Experimental Models
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    Chapter 17 Diuretic and Saluretic Activity
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    Chapter 18 Assessment of Renal Function
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    Chapter 19 Impaired Renal Function
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    Chapter 20 Uricosuric and Hypo-Uricemic Activity
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    Chapter 21 Drug Influence on Lower Urinary Tract
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    Chapter 22 Binding Tests in Respiratory System
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    Chapter 23 Effects of Drugs on Air Ways
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    Chapter 24 Antitussive Activity
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    Chapter 25 Effects on Tracheal Cells and Bronchial Mucus Secretion
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    Chapter 26 Effects on Behavior and Muscle Coordination
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    Chapter 27 Tests for Anxiolytic Activity
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    Chapter 27 Tests for Anxiolytic Activity
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    Chapter 28 Anti-Epileptic Activity
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    Chapter 29 Hypnotic Activity
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    Chapter 30 Neuroleptic Activity
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    Chapter 30 Neuroleptic Activity
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    Chapter 31 Antidepressant Activity
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    Chapter 31 Antidepressant Activity
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    Chapter 32 Anti-Parkinson Activity
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    Chapter 32 Anti-Parkinson Activity
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    Chapter 33 Animal Models of Neurological Disorders
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    Chapter 33 Animal Models of Neurological Disorders
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    Chapter 34 General Anesthetics
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    Chapter 35 NMRI Methods in Psychoneuropharmacology
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    Chapter 35 NMRI Methods in Psychoneuropharmacology
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    Chapter 36 Nonbehavioral Methods Used in the Study of Learning and Memory
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    Chapter 37 Behavioral Methods Used in the Study of Learning and Memory
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    Chapter 38 Local Anesthetic Activity
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    Chapter 39 Neuromuscular Blocking Activity
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    Chapter 40 Central Analgesic Activity Central analgesic activity
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    Chapter 41 Peripheral Analgesic Activity
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    Chapter 42 Anti-inflammatory Activity
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    Chapter 43 Antipyretic Activity
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    Chapter 44 Anti-Arthritic Activity
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    Chapter 45 Methods for Testing Immunological Factors
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    Chapter 47 Influence of Lipid Metabolism
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    Chapter 48 Inhibition of Cholesterol Biosynthesis
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    Chapter 49 Inhibition of Cholesterol Absorption
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    Chapter 50 Interruption of Bile Acid Recirculation
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    Chapter 51 Inhibition of Lipid Oxidation
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    Chapter 52 Internalization of Labeled LDL into HepG2 Cells
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    Chapter 53 Influence of Peroxisome Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs) on Development of Artherosclerosis
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    Chapter 54 Test on Salivary Glands
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    Chapter 55 Tests on Esophagus
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    Chapter 56 Pharmacological Effects on Gastric Function
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    Chapter 57 Pharmacological Effects on Intestinal Functions
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    Chapter 58 Emetic and Antiemetic Activity
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    Chapter 59 Gallbladder Function
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    Chapter 60 Pancreatic Function
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    Chapter 61 Liver Function
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    Chapter 63 Methods to Induce Experimental Diabetes Mellitus
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    Chapter 64 Genetically Diabetic Animals
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    Chapter 65 Measurement of Blood Glucose-Lowering and Antidiabetic Activity
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    Chapter 66 Measurement of Insulin and Other Glucose-Regulating Peptide Hormones
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    Chapter 67 Insulin Target Tissues and Cells
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    Chapter 68 Assays for Insulin and Insulin-Like Metabolic Activity Based on Hepatocytes, Myocytes, and Diaphragms
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    Chapter 70 Monitoring of Diabetic Late Complication
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    Chapter 71 Insulin Analogs: Assessment of Insulin Mitogenicity and IGF-I Activity
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    Chapter 72 Methods to Induce Experimental Obesity
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    Chapter 73 Genetically Obese Animals
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    Chapter 74 Assays of Anti-obesity Activity
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    Chapter 75 Assays of Obesity-Regulating Peptide Hormones
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    Chapter 76 Adrenal Steroid Hormones
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    Chapter 77 Ovarian Hormones
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    Chapter 78 Testicular Steroid Hormones
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    Chapter 79 Thyroid Hormones
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    Chapter 80 Parathyroid Hormones
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    Chapter 81 Anterior Pituitary Hormones
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    Chapter 82 Posterior Pituitary Hormones
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    Chapter 83 Hypothalamic Hormones
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    Chapter 84 Effects on Different Peptide Hormones
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    Chapter 85 Intraocular Pressure
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    Chapter 86 Aqueous Humor Flow Rate
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    Chapter 87 Experimental Glaucoma
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    Chapter 88 Local Anesthesia of the Cornea
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    Chapter 89 Experimental Cataract Formation
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    Chapter 90 Models on Eye Inflammation
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    Chapter 91 Pharmacologic Intervention for Acquired Hearing Loss: Assays of Drug-Induced Inner Ear Damage
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    Chapter 92 Neurobiology and Pharmacology of Sleep Disorders in Otolaryngology: Head and Neck Surgery
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    Chapter 93 Experimental Tinnitus
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    Chapter 94 Skin Sensitization Testing
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    Chapter 95 Experimental Dermatitis
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    Chapter 96 Pruritus Models
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    Chapter 97 Psoriasis Models
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    Chapter 98 Scleroderma Models
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    Chapter 99 Pemphigus Models
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    Chapter 100 Ichthyosis Models
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    Chapter 101 Xeroderma Models
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    Chapter 102 Vitiligo Models
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    Chapter 103 Erythropoietic Protoporphyria
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    Chapter 104 Acne Models
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    Chapter 105 Skin Mycosis
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    Chapter 106 Biomechanics of Skin
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    Chapter 107 Protection Against UV Light
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    Chapter 108 Transepidermal Water Loss
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    Chapter 109 Skin Hydration
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    Chapter 110 Influence on Hair Growth
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    Chapter 111 Cutaneous Microcirculation
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    Chapter 112 Isolated Perfused Skin Flap
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    Chapter 113 Oncology Activity
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    Chapter 114 Stem Cells in Drug Development
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    Chapter 115 Quantitative Metabolomics
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    Chapter 116 Quantitative Glycoproteomics
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    Chapter 117 Personalized Medicine
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    Chapter 119 Herbal Medicine
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    Chapter 120 Overview of What Functional Foods Are
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    Chapter 121 Regulation of Functional Foods and Ingredients
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    Chapter 122 Benefit Claims of Functional Food
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    Chapter 123 Safety Assessment of Functional Foods
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    Chapter 124 Post-Launch Monitoring
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    Chapter 125 Impact of Functionality on Safety Risk Assessment
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    Chapter 131 Regulations for the Care and Use of Laboratory Animals in Various Countries
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    Chapter 132 Techniques of Blood Collection in Laboratory Animals
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    Chapter 133 Anesthesia of Experimental Animals
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    Chapter 134 Euthanasia of Experimental Animals
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    Chapter 135 Zebrafish
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    Chapter 136 History of Safe Use History of safe use approach
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    Chapter 137 Orphan Drugs
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    Chapter 138 Induction of Experimental Atherosclerosis
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    Chapter 139 Experimental Models for Drug Evaluation in Noise-Induced Hearing Loss and Age-Related Hearing Impairment
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    Chapter 140 Adenosine Receptors
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    Chapter 140 Effects of Adenosine Receptors
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    Chapter 141 Renin–Angiotensin System
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    Chapter 142 PAF-Binding and Endothelins Activity
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    Chapter 143 NO Activity and Rho Kinase Activity
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    Chapter 144 Na + /H + Exchange
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    Chapter 145 Phosphodiesterases and the Effects of Forskolin
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    Chapter 146 Patch-Clamp and Voltage-Clamp Techniques
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    Chapter 147 Effect of Different Peptides
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    Chapter 148 Different Channels
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    Chapter 150 Advances in Antiplatelets
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    Chapter 151 Advances in Anticoagulants
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    Chapter 152 Personalized Diagnosis and Therapy
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    Chapter 153 Measurement of Glucose Absorption
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    Chapter 154 Assays for Insulin and Insulin-Like Activity Based on Adipocytes
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    Chapter 155 Assays for Insulin and Insulin-Like Regulation of Energy Metabolism
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    Chapter 156 Assays for Insulin and Insulin-Like Regulation of Gene and Protein Expression
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    Chapter 157 Assays for Insulin and Insulin-Like Signal Transduction Based on Adipocytes, Hepatocytes, and Myocytes
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    Chapter 158 Assays for the Expression and Release of Insulin and Glucose-Regulating Peptide Hormones from Pancreatic β-Cell
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Title
Drug Discovery and Evaluation: Pharmacological Assays
Published by
Springer Berlin Heidelberg, January 2014
DOI 10.1007/978-3-642-27728-3
ISBNs
978-3-64-227728-3
Editors

Hock, Franz J.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 202 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Portugal 1 <1%
Brazil 1 <1%
Italy 1 <1%
United Kingdom 1 <1%
Luxembourg 1 <1%
Unknown 195 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 12%
Student > Ph. D. Student 23 11%
Student > Master 23 11%
Student > Bachelor 21 10%
Student > Doctoral Student 15 7%
Other 37 18%
Unknown 58 29%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 49 24%
Medicine and Dentistry 21 10%
Agricultural and Biological Sciences 17 8%
Chemistry 14 7%
Biochemistry, Genetics and Molecular Biology 12 6%
Other 25 12%
Unknown 64 32%