Chapter title |
Eosinophils interaction with mast cells: the allergic effector unit.
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Chapter number | 20 |
Book title |
Eosinophils
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Published in |
Methods in molecular biology, July 2014
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DOI | 10.1007/978-1-4939-1016-8_20 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1015-1, 978-1-4939-1016-8
|
Authors |
Gangwar RS, Levi-Schaffer F, Roopesh Singh Gangwar, Francesca Levi-Schaffer, Gangwar, Roopesh Singh, Levi-Schaffer, Francesca |
Abstract |
Mast cells (MC) and eosinophils are the key effector cells of allergy (Minai-Fleminger and Levi-Schaffer, Inflamm Res 58:631-638, 2009). In general, allergic reactions have two phases, namely, an early phase and a late phase. MC and eosinophils abundantly coexist in the inflamed tissue in the late and chronic phases and cross talk in a bidirectional manner. This bidirectional interaction between MC and eosinophils is mediated by both physical cell-cell contacts through cell surface receptors such as CD48 receptors CD48, 2B4 , 2B4 and soluble mediators through various specific granular mediators, arachidonic acid metabolites, cytokines cytokines , and chemokines, collectively termed the "Allergic Effector Unit" (AEU) (Elishmereni et al., Allergy 66:376-385, 2011; Minai-Fleminger et al., Cell Tissue Res 341:405-415, 2010). These bidirectional interactions can be studied in vitro in a customized coculture system of MC and eosinophils derived from either mouse or human source. |
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Members of the public | 1 | 50% |
Mendeley readers
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Student > Bachelor | 1 | 13% |
Researcher | 1 | 13% |
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Unknown | 2 | 25% |