Peptide Science — Present and Future

Table of Contents

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   Book Overview
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   Chapter 1 From big molecules to smaller ones
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   Chapter 2 Directions for solving the remaining problems in the synthesis of large peptides
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   Chapter 3 Peptide science: past, present and future
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   Chapter 4 Quo vadis? Where is peptide chemistry headed?
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   Chapter 5 Designing peptidomimetic antagonists for peptide receptors: topochemical differences of agonists and antagonists
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   Chapter 6 Self-assembling homopolymeric peptide tapes in aqueous solution
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   Chapter 7 Peptides containing nonnatural amino acids with functional side groups
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   Chapter 8 Active carbonates of N -protected amino alcohols for synthesis of carbamate pseudopeptides
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    Chapter 9 Convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins and its application to the synthesis of bifunctional anti-HIV compounds
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    Chapter 10 Stereoselective synthesis of two type ( E )-alkene dipeptide isosteres from a single substrate of β-aziridinyl- α,β-enoate
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    Chapter 11 Design and synthesis of conformationally constrained dipeptide containing the α-fluoroglycine residue
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    Chapter 13 Molecular assembly of helix peptides vertically oriented on gold surface
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    Chapter 14 Gramicidin vesicles — self-assembly in water composed of gramicidin A as hydrophobic core of membrane
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    Chapter 15 Design, synthesis, and characterization of a dimeric analog of small globular protein (SGP) in solution and its biological and channel-forming activities
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    Chapter 16 Molecular design of cyclic peptides containing a non-natural amino acid: novel synthetic approach to artificial ion channels
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    Chapter 17 Structure based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor
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    Chapter 18 A three-helix bundle metallopeptide destabilized at an acidic condition
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    Chapter 19 The alamethicin-leucine zipper hybrid peptide: modulation of the assembling of transmembrane peptides through the extramembrane peptide segments
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    Chapter 20 BCvir: backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in non-dividing cells
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    Chapter 21 Self-assembling homopolymeric peptide tapes in moderately polar organic solvents
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    Chapter 22 Substrate specificities of artificial flavo-enzymes
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    Chapter 24 Catalytic activities of an artificial heme enzyme
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    Chapter 25 A novel dioxopiperazine suitable as a β-turn constraint
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    Chapter 26 Amphiphilic β-structure formed by oligopeptides composed of alternating hydrophic and hydrophobic residues
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    Chapter 27 Design of cyclic antimicrobial peptides with low hemolytic activity
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    Chapter 28 Synthesis and characterization of linear and cyclic oligopeptides of 5-alkyl-substituted 3-aminobenzoic acids
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    Chapter 29 Theoretical analysis of βββββ-type packing motifs formed by alternate intramolecular arrangements of three β-helices and three β-strands
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    Chapter 30 Theoretical analysis of β-type packing motifs formed by intramolecular arrangements of β- strands
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    Chapter 31 Theoretical analysis of βββ-type packing motifs formed by intramolecular arrangements of two β-helices and two β-strands
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    Chapter 32 Self-catalytic conversion of peptides from β-helix to β-structural amyloid
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    Chapter 33 Design, synthesis and characterization of heme-conjugated two-β-helix peptides
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    Chapter 34 Self-assembly of heme-conjugated two-β-helix peptides
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    Chapter 35 Construction of porphyrin-binding peptides mimicking anti-heme monoclonal antibody
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    Chapter 36 Construction of cyclodextrin-peptide conjugates and their molecular sensing properties
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    Chapter 38 Topographically designed analogues of c[ d -Pen 2 , Pen 5 , Nle 6 ] deltorphin I with stereoisomers of β-MePhe or β-iPrPhe in position 3
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    Chapter 39 Engineering novel mini-proteins by the transfer of active sites to small disulfide stabilized natural scaffolds
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    Chapter 40 Preparation of heterocyclic positional scanning combinatorial libraries from peptides
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    Chapter 41 Design and synthesis of a lactam bridge stabilized coiled-coil template for library display
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    Chapter 42 Diversity of synthetic peptides
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    Chapter 43 Manual construction of combinatorial resin bound tripeptide library (one peptide on one bead) and screening to find antioxidative peptides
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    Chapter 44 Selection of peptides that bind to β-lactalbumin from phage display library
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    Chapter 45 Identification of a novel analgesic peptide including an unnatural amino acid from peptide libraries synthesized with a multipeptide synthesizer
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    Chapter 46 Artificial proteins screened from combinatorial chemical libraries with strong binding to double-stranded oligodeoxyribonucleotides: towards repressors to long terminal repeat controlled viral transcription
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    Chapter 47 Synthesis, conformational analysis and application of tropane-based Fmoc-amino acid derivatives: novel antagonists of fibrinogen receptor, GPIIb/IIIa
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    Chapter 48 Accurate peptide sequencing by mass spectrometry
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    Chapter 49 Characterization of sulfhydryl compounds attached to the cysteinyl residue of proteins or peptides by on-line post-column derivatization
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    Chapter 50 Regioselective hydrolytic cleavage of N -terminal myristoyl-peptide
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    Chapter 52 Hydrolytic removal of acetyl-amino acid from acetyl- peptide in methanesulfonic acid
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    Chapter 53 Determination of the binding-site structure of the atrial natriuretic peptide receptor by stepwise-affinity alkylation
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    Chapter 55 Photophysics of sterically constrained phenylalanines
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    Chapter 56 Addressing combinatorial and peptide analysis by using overpressured layer chromatography in comparison with high-performance liquid chromatography and capillary electrophoresis
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    Chapter 58 The mechanisms of exocytosis induced by neurokinin peptides in mast cells
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    Chapter 59 Effects of dynorphins on free cytoplasmic calcium concentration and insulin release in ob/ob mouse pancreatic β-cells
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    Chapter 60 The effect of magnesium ions on the uterotonic activity of oxytocin analogs
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    Chapter 61 Human thymopoietin beta-fragments: synthesis and antibody studies
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    Chapter 62 Cholecystokinin receptor parameters responsible for specific cellular signalling
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    Chapter 63 Sweetness-suppressing activities of gurmarin analogues missing one disulfide bond
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    Chapter 64 Modeling of the somatostatin receptor (hsst3)-ligand complex
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    Chapter 65 Structural requirements of hyperalgesic nociceptin in receptor binding and activation
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    Chapter 67 Agonist-antagonist structure-activity relationships of thrombin receptor tethered ligand peptide
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    Chapter 68 The first extracellular loop of the rat glucagon receptor contains determinants of glucagon binding
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    Chapter 69 A novel type of rat brain β opioid receptors differenciated by cyclopropylphenylalanine-containing enkephalin analog
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    Chapter 70 Synthesis of dimeric novobiocins as chemical inducers of dimerization for DNA gyrase-fused proteins
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    Chapter 71 Computer biochemistry and molecular physiology of the natural peptide ligands: different functional groups
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    Chapter 72 Bacterial peptide pheromone is imported where it directly binds to an intracellular receptor
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    Chapter 73 Grb2 SH2 domain targeted inhibitors functioning in cellular signaling
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    Chapter 74 74]Interaction between heat-stable enterotoxin and its receptor (guanylyl cyclase C): Influence of mutation at N -linked glycosylation sites on its ligand binding
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    Chapter 75 Receptor studies with novel insulin analogues and photoaffinity labelling techniques
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    Chapter 76 Radioligands for the receptor of mammalian melanin-concentrating hormone (MCH)
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    Chapter 77 Using peptides to study the folding of a predominantly β-sheet protein
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    Chapter 78 β-Helical propensity of Ala-based peptides in organic solvents
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    Chapter 79 Effects on folding properties of endothelin/apamin by incorporation of selenocysteine into their cysteine framework
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    Chapter 80 Peptide conformational behaviour studied by high and low temperature reversed phase HPLC
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    Chapter 81 Three-dimensional structure and receptor-recognition sites of bombyxin-II, an insulin-like brain-secretory peptide of the silkmoth
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    Chapter 82 C β -Methyl, C β -phenylglycine peptides
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    Chapter 84 The E. Fischer’s octadecapeptide revisited after 90 years
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    Chapter 85 Conformational analysis of peptide fragments corresponding to domains of potassium ion-channel proteins
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    Chapter 86 Conformation and sweet taste of l -Asp- d -Xaa-OMe dipeptides
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    Chapter 87 Conformations of four cyclic tetrapeptides containing two Pro residues
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    Chapter 89 Formation of native disulphide bonds in endothelin-1: evidence for the involvement of a highly specific salt-bridge between the pro-sequence of endothelin-1 and mature sequence
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    Chapter 90 Structure-biological activity relationships of cecropin A (1–8)-magainin 2 (1–12) hybrid and its analogues
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    Chapter 91 Structure-activity relationship of βagatoxin-TK, a peptide blocker of P/Q-type calcium channels
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    Chapter 93 Structure analysis of the second transmembrane segment of the rat bradykinin receptor in solution and in micelles by CD and fluorescence spectroscopies
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    Chapter 94 Conformational analysis of antimicrobial peptide tachystatin A isolated from horseshoe crab hemocytes by two dimensional 1 H NMR spectroscopy
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    Chapter 95 Solution structure of β-conotoxin MI determined by 1 H-NMR spectroscopy and molecular dynamics simulation with the explicit solvent water
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    Chapter 96 Study of depsipeptide Boc-(Leu-Leu-Ala) 2 -(Leu-Leu- Lac) 3 -OEt forming 3 1 0 -helix
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    Chapter 97 1 H Nuclear Magnetic Resonance analysis of [Ser 6 , Ser 20 ]-human-Epidermal Growth Factor as a model for the intermediate of the disulfide folding pathway
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    Chapter 98 p K a shift by NH⋯S hydrogen bond in the hair-pin turn structure of Cys-containing oligopeptides
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    Chapter 99 Effect of environment on the stability of helical Aib-model peptides
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    Chapter 100 Structural analysis of mastoparan by solid-state nuclear magnetic resonance
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    Chapter 101 Four-helix bundle formation only through special pathway via micelle state
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    Chapter 102 Synthesis of peptides containing 9-aminofluorene- 9-carboxylic acid by the modified Ugi reaction
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    Chapter 105 Solution structure of the extracellular domain of type-I receptor for bone morphogenetic protein-2/4 as studied by nuclear magnetic resonance spectroscopy
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    Chapter 106 Comparison of three-dimensional solution structures of dendrotoxin I, a potassium channel blocker, and calucicludine, a calcium channel blocker, determined by nuclear magnetic resonance spectroscopy
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    Chapter 107 Sequence, conformation, and function of peptides, retro peptides and sense and antisense gene products
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    Chapter 108 Ion conductance in a gramicidin channel: the right-handed double-stranded double-helical dimer
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    Chapter 109 Protein folding intermediates and Alzheimer’s disease
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    Chapter 110 Topological isomers of human uroguanylin: function and conversion
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     Chapter 111 Topological isomers of human uroguanylin: structure determination by nuclear magnetic resonance
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     Chapter 112 Homology modelling of the glycoprotein hormones: examination of the receptor recognition characteristics
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     Chapter 115 Receptor based design, synthesis and biology of novel somatostatin analogs
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     Chapter 116 NMR structure of mastoparan-X bound to G protein β subunit
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     Chapter 119 Characterization and evolutionary aspect of a Trimeresurus flavoviridis serum inhibitor, PLI-I, against its venom basic phospholipase A 2 isozymes
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     Chapter 121 Phosphorylation of synthetic peptides containing proline homologs by cdc2 kinase or cdk5
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     Chapter 122 Synthesis of oligomerization domain of p53 and its analogs and their association properties in buffer solution
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     Chapter 124 Circular dichroism and fluorescence study of the interaction of synthetic J protein from bacteriophage βK with DNA
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     Chapter 125 Unusual collagen assembly induced by acidic biopolymers in vitro
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     Chapter 126 The role of nucleoplasmin — molecular chaperone protein — in the fertilization process
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     Chapter 127 Conformation of chick DNA topoisomerase I as determined by limited proteolysis
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     Chapter 128 The two adenosine triphosphate and nucleic acid binding sites of the calf thymus single-strand DNA-dependent adenosine triphosphatase
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     Chapter 129 Induced helical structure in highly charged peptides
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     Chapter 130 Nociceptin, a novel neuropeptide with multiple functions
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     Chapter 131 An anti-HIV peptide T22 is confirmed to be a selective CXCR4/fusin inhibitor by comparative inhibition study of a chemokine SDF-1, synthesized by regioselective disulfide bond formation
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     Chapter 132 Isolation of the nucleoplasmin-like molecular chaperone protein from salmon egg
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     Chapter 133 Study of neurotoxic peptides from Chinese scorpion Buthus martensi Karsch
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     Chapter 134 Impervious peptides as growth hormone secretagogues
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     Chapter 136 Morphological differences observed by the different modes of action of the antibacterial peptides, cecropin B and its analogs CB-1, CB-2 and CB-3 on bacterium and cancer cell
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     Chapter 137 Isolation and characterization of bioactive peptides from the sea cucumber, Stichopus japonicus
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     Chapter 138 Purification of peptide fractions with anticomplementary activity from red ginseng ( Panax ginseng , C.A. Meyer)
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     Chapter 139 HIV-cell fusion inhibitor, T22 ([Tyr 5,12 , Lys 7 ]-polyphemusin II), and its related compounds
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     Chapter 140 Efficient analogs of an anti-HIV peptide, T22 ([Tyr 5,12 , Lys 7 ]-polyphemusin II), having low cytotoxicity
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     Chapter 141 Cyclic RGD peptides with a novel mimetic
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     Chapter 143 Eumenine mastoparans. A new class of mast cell degranulating peptides in the eumenine wasp venom
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     Chapter 144 Direct evidence of the generation of lactoferricin from ingested lactoferrin
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     Chapter 146 A novel cardioactive peptide of Aplysia contains a d -amino acid residue
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     Chapter 148 Structure and function of fragments of antibiotic bactenecin 5
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     Chapter 149 Production of adrenomedullin in macrophages
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     Chapter 150 Adrenomedullin production in fibroblast cell lines
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     Chapter 151 Chemical and biological characterization of neuropeptides in the sinus glands of the kuruma prawn, Penaeus japonicus
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     Chapter 153 Modification of an anti-fungal peptide (ESF-1) for enhanced inhibitory activity and resistance to proteolysis
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     Chapter 154 Structure determination and cDNA cloning of paralytic peptide in Bombyx mori
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     Chapter 156 Synthesis, conformational analysis, and biological activity of opioid peptide analogs containing side chain fluorinated amino acids
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     Chapter 157 Structural requirement tryptophan 1,3 of tridecapeptide mating pheromone of Saccharomyces cerevisiae
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     Chapter 158 Synthesis and in vitro effects of short analogues of β-amyloid peptide on resting transmembrane potential
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     Chapter 159 Macrotorials: synthesis and characterization of model compounds related to PTH (1–34)
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     Chapter 160 Developments in peptide synthesis and peptidomimetic chemistry: HIV protease analogs and substrate-based inhibitors
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     Chapter 161 Thia zip reaction for the facile synthesis of large cyclic peptides
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     Chapter 162 Synthesis of disulfide-bridged heterotrimeric collagen peptides. Conformational properties and digestion by matrix metalloproteinases
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     Chapter 163 Combined solid-phase and solution approach to protein synthesis
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     Chapter 165 Stereoselective synthesis of dehydroaminobutyric acid
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     Chapter 166 Efficient preparation of dehydroalanine derivatives
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     Chapter 167 Totally stereocontrolled synthetic routes for ( E )-alkene dipeptide isosteres
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     Chapter 168 Synthesis of protected 2,3-epoxy amines utilizing aza-Payne rearrangement of activated 2-aziridinemethanols under basic conditions
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     Chapter 169 Convenient preparation of phosphopeptide fragments using High TFMSA system and its application to synthesis of long chain phosphopeptides
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     Chapter 170 An efficient synthesis of tryptophan-containing cystine peptide using the silyl chloride-sulfoxide system
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     Chapter 171 Synthesis of an HIV-1 protease dimer analog covalently linked by a disulfide bridge
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     Chapter 174 Synthetic approach to microsclerodermins
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     Chapter 175 Synthetic approach to caledonin, a natural bolaphile
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     Chapter 176 Synthetic approach to antillatoxin, an exceptionally ichthyotoxic cyclic lipodepsipeptide
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     Chapter 177 Desulfation vs. deprotection: direct solid-phase synthesis of Tyr(SO 3 H)-containing peptides using the S n 1-type deprotection procedure
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     Chapter 178 Enzymatic syntheses of oligopeptides in organic solvents
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     Chapter 179 Studies of racemization in peptide synthesis for a phosphoryloxy-benzotriazin-one coupling reagent (DEPBT)
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     Chapter 180 Effect of polyethylene glycol on the synthesis of oligopeptides by proteases in an organic medium
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     Chapter 181 Synthesis of a cyclic tetrapeptide related to trapoxin B
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     Chapter 182 Highly efficient solid phase cyclization of peptides by methylenedithioether or disulfide bond formation
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     Chapter 183 4-(2-(1-Hydroxyethyl)-1,3-dithiacyclohex-2-yl)-phenoxyacetic acid (HETPA): photolabile linker for Fmoc solid phase synthesis
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     Chapter 184 Kinetic study of the pseudolysin-catalyzed synthesis of Z-Ala-Phe-NH2
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     Chapter 185 Solid phase peptide synthesis using 2-(4-Nitrophenyl)-sulfonylethoxycarbonyl (NSC) amino acids for Luteinizing hormone-releasing hormone (LHRH)
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     Chapter 186 Novel synthesis through repeated S -cyanocysteine mediated segment condensations
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     Chapter 187 Total synthesis of human pleiotrophin, a 136-residue heparin-binding neurotrophic factor having five disulfide bonds
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     Chapter 188 Engineering of snake venom cardiotoxin by chemical synthesis approach
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     Chapter 189 Specificity of Cardosins A and B in peptide synthesis
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     Chapter 191 ESR-resin solvation approach for the investigation of the highly peptide-loaded synthesis protocol
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     Chapter 192 Synthesis of β-amino phosphonic acids by catalytic asymmetric hydrogenation
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     Chapter 193 Process impurity identification in MSI-78
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     Chapter 194 Identification of unknown intermediate during methanolysis of Z-Lys (Boc)—OSu
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     Chapter 195 Synthesis of phosphorylated polypeptide by a thioester method
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     Chapter 196 Synthesis of reaper protein by a thioester method using silver chloride as an activator
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     Chapter 197 Preparation of a peptide thioester by a 9-fluorenylmethoxycarbonyl solid phase method
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     Chapter 198 Chemical synthesis of barnase which possesses phosphoserine residue in place of the catalytic glutamic acid at position 73
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     Chapter 199 Disulfide oxidation in water: investigation of CLEAR supports for on-resin cyclization
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     Chapter 200 Non-natural peptide modifications using sugars and lipophilic side chains
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     Chapter 201 Diastereoselective synthesis of glycosyl-β-aminoacids and glycopeptide derivatives
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     Chapter 202 Influence of glycation on cis/trans isomerization and tautomerization in novel morphiceptin-related Amadori compounds
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     Chapter 203 Chemoenzymatic synthesis of glycophosphopeptides
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     Chapter 204 Design and synthesis of novel Src homology-2 domain inhibitors
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     Chapter 205 Chemo-enzymatic syntheses of eel calcitonin analogs having natural N -linked oligosaccharides
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     Chapter 206 Chemo-enzymatic synthesis of bioactive peptide derivatives containing N -linked oligosaccharides
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     Chapter 207 Optimization of N,N ′-dialkyldiamide-type phosphate protecting group for phosphopeptide synthesis
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     Chapter 208 Solid phase synthesis of O -glycopeptide — Preparation of O -( N -acetylgalactosaminyl)-threonine derivative and its application to peptide synthesis
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     Chapter 210 Development of potent non-peptide GPIIb/IIIa antagonists with tri-substituted β-amino acid derivatives as a new conformational restriction unit
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     Chapter 211 Design and synthesis of potent and selective inhibitors of the osteoclast-specific cysteine protease, cathepsin K
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     Chapter 212 Difference of structural requisite in design of inhibitor of cathepsin B and papain: X-ray crystal structures of complexes
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     Chapter 213 Synthesis of peptides with aziridine-2,3-dicarboxylic acid as an β-amino acid equivalent building block
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     Chapter 214 Isolation and characterization of prolyl endopeptidase-inhibiting peptides from bovine brain
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     Chapter 215 Structure based design and synthesis of novel orally active thrombin inhibitors
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     Chapter 216 Design of bivalent plasmin inhibitors
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     Chapter 217 Suicide-inhibition of human immunodeficiency virus type-1 protease by the gag precursor processing product (p2 gag peptide)
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     Chapter 218 Design of plasma kallikrein selective inhibitor and its application to affinity chromatography
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     Chapter 219 Structural essentials for novel inhibition of serine protease chymotrypsin
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     Chapter 220 KNI-764, A novel dipeptide-based HIV protease inhibitor containing allophenylnorstatine
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     Chapter 221 Self-association of cystatin
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     Chapter 222 The substrate specificity of microbial carboxyl proteinases
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     Chapter 223 Allophenylnorstatine containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 and P2′ ligands
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     Chapter 224 Allophenylnorstatine containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 ligands
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     Chapter 225 Opioid peptide analogs with novel activity profiles as potential therapeutic agents for use in analgesia
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     Chapter 226 Peptide radiopharmaceuticals: studies of somatostatin receptors and ligands for tumor targeting
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     Chapter 227 Fatty acid acylated insulins display protracted action due to binding to serum albumin
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     Chapter 228 Melanotropin fragments containing difluoromethylornithine: synthesis and cytotoxicity
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     Chapter 229 Synthesis of RANTES-related peptides and their effect on human immunodeficiency virus-1 infection
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     Chapter 230 The influence of structural motifs of amphipathic peptides on the permeabilization of lipid bilayers and the antibacterial and hemolytic activity
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     Chapter 231 Proline at position 14 of alamethicin is essential for the hemolytic activity, catecholamine secretion from chromaffin cells and enhanced metabolic activity in endothelial cells
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     Chapter 232 Enkephalin metabolism in rat brain after bestatin administration
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     Chapter 233 Synthetic antibacterial peptides derived from insect defensin isolated from a beetle, Allomyrina dichotoma
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     Chapter 234 Do peptide antioxidants increase neuron viability by direct antioxidant effect?
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     Chapter 235 Synthesis and characterization of β-conotoxin TxVII
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     Chapter 236 Design and synthesis of antifungal lactoferricin derivatives
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     Chapter 237 Incorporation of the nuclear localization signal (NLS) peptide-albumin conjugate to macrophages using pH-sensitive liposomes
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     Chapter 238 Dermorphin-dynorphin hybrid analogs: Opioid receptor selection and enzymatic stability
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     Chapter 239 Selective cytotoxicity of dermaseptins
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     Chapter 240 Synergism of antimicrobial peptides, magainin 2 and PGLa, in liposomes
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     Chapter 241 Cell specific gene transfer using galactose-modified peptide
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     Chapter 242 Synthesis and biological activities of hPTH)1—34) analogues: modification of the middle part and C -terminal alkylamides
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     Chapter 243 Absolute importance of arginine residue at position 7 of dog neuromedin U-8 for contractile activity
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     Chapter 244 Cyclic peptides having inhibitory site of β-amylase inhibitor tendamistat
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     Chapter 245 Doxorubicin liposomal preparations coated with Laminin related peptides
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     Chapter 246 Importance of hydrophobic region in cationic peptides on gene transfer into cells and enhance effect of lysosome-disruptive peptide
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     Chapter 247 Synthesis and pharmacological properties of oxytocin antagonists containing conformationally constrained amino acids
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     Chapter 248 Identification of the structural elements responsible for high biological activity of dimeric opioid peptide biphalin
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     Chapter 249 Orally active memory-enhancing peptides obtained by designing bioactive peptides derived from food proteins
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     Chapter 250 Dimers of bradykinin and substance P antagonists as potential anti-cancer drugs
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     Chapter 251 Ovine Leydig cell insulin-like peptide: a sheep relaxin?
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     Chapter 252 Self-assembling peptides in biology, materials science and engineering
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     Chapter 253 Hybridization properties of nucleic acid analogs bearing peptide backbone
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     Chapter 254 Copper(II) complexes of the modified ACTH active center analogue hexapeptides — investigation by means of CD spectroscopy
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     Chapter 255 The structure—activity relationships of the sweet protein brazzein — roles of acidic amino acids
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     Chapter 256 Asymmetric synthesis of β-amino acids: Dynamic kinetic resolution utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary
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     Chapter 257 The function and insertion of a d -Serine residue in β- agatoxin-TK
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     Chapter 258 Physiological role of the delta sleep-inducing peptide (DSIP)
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     Chapter 259 Comparison of secondary structure and antibacterial activity of bactericidal peptides derived from bovine and Korean native goat lactoferrin
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     Chapter 260 Synthesis of enantiomerically pure non proteinogenic β-amino acids
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     Chapter 261 Improvements of activity and stability against proteases of biologically active peptides by coupling of a cyclic peptide derived from an endothelin antagonist RES-701-1
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     Chapter 262 Structure-activity relationship of cyclic depsipeptides, AM-toxin analogs
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     Chapter 263 Effects of chemical modification of Ca 2+ -dependent lectin CEL-III on its hemolytic and carbohydrate-binding activities
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     Chapter 264 Coacervation of elastomeric polypeptides: microscopic observations and light scattering measurements
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     Chapter 265 Preparation and properties of novel gramicidin S analogs possessing a polymethylene bridge between ornithine side chains
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     Chapter 266 Effect of nitroprusside on amyloid peptide induced inhibition of MTT reduction in pheochromocytoma PC12h and C1300 neuroblastoma cells
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     Chapter 267 Practical approach to enzymatic resolution of Fmoc- and Boc-protected amino acid racemates
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     Chapter 268 Rapid translocation of amphipathic βhelical and β-sheet-forming peptides through plasma membranes of endothelial cells
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     Chapter 269 Peptide analogues as vaccines and immunomodulators
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     Chapter 270 Combinatorial peptide libraries and molecular recognition in T-cell mediated immune response
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     Chapter 271 On the puzzle of the acute phase reactants C-reactive protein and serum amyloid A
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     Chapter 272 Design of peptidic and non-peptidic CD4 inhibitors as novel immunotherapeutic agents [1–5]
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     Chapter 273 Molecular design of T cell-costimulatory peptides for vaccine development
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     Chapter 274 The identification of dominant epitopes of h-FKBP-12 recognized by monoclonal antibodies, 3F4 and 2C1, against h-FK-506 binding protein 12(h-FKBP-12)
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     Chapter 275 Contribution of peptide backbone atoms to binding of an antigenic peptide to class I major histocompatibility complex molecule
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     Chapter 276 B cell and T cell epitopes of Der f 2, a house dust mite major allergen of the Dermatophagoides farinae
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     Chapter 277 Conformational and binding studies of the peptide isolated from phage display library by anti-mouse CTLA-4 monoclonal antibody
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     Chapter 278 Formation of DNA-anti-DNA antibody immune complex on collagen matrix
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     Chapter 279 Natural IgM antibodies against human endogenous retroviruses HERV-H demonstrated by means of synthetic peptides
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     Chapter 280 Evaluation of region-specific antibodies for rat and human Chromogranin A with use of synthetic peptide
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     Chapter 281 Design of synthetic antigen containing non-immunogenic T cell epitope core and simple non-native flanking regions
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     Chapter 282 Immune response to newly exposed regions of Band 3 protein of the red blood cell membrane during malaria infections
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     Chapter 283 Peptide-induced antibodies as a tool to link genomes and proteomes
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     Chapter 284 Porphyrin-peptide conjugates with stabilized helices and sheets
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     Chapter 285 Molecular recognition of cyclic HIV protease inhibitors: highly orally-bioavailable DMP851