Chapter title |
Effects of voluntary exercise and/or food restriction on pancreatic tumorigenesis in male rats.
|
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Chapter number | 3 |
Book title |
Exercise, Calories, Fat and Cancer
|
Published in |
Advances in experimental medicine and biology, January 1992
|
DOI | 10.1007/978-1-4684-7953-9_3 |
Pubmed ID | |
Book ISBNs |
978-1-4684-7955-3, 978-1-4684-7953-9
|
Authors |
Giles, T C, Roebuck, B D, Giles, Theresa C., Roebuck, B. D. |
Abstract |
Studies were undertaken to evaluate the effects of caloric restriction on voluntary exercise in a rat model of pancreatic cancer. Suckling male Lewis rats were initiated with 3 doses (30 mg/kg body weight) of the pancreatic carcinogen azaserine. At 28 days of age they were weaned to one of four experimental protocols; namely, sedentary/ad libitum fed, voluntary exercise/ad libitum fed, sedentary/food restricted, and voluntary exercise/food restricted. Voluntary exercise was provided by free access to running wheels fitted with odometers. Food restriction was intended to be mild, at less than 10% reduction of ad libitum intake. Putative pre-neoplastic pancreatic foci were identified microscopically at 4 months post-azaserine treatment. As previously shown, food restriction led to increased wheel activity, but the increased activity could not be maintained beyond the first half of the post-initiation treatment phase. Additionally, the extensive wheel running occurred only when available food was restricted by greater than 10%. Exercise per se had a lesser effect compared to food restriction on pancreatic tumorigenesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 1 | 17% |
Professor > Associate Professor | 1 | 17% |
Researcher | 1 | 17% |
Unknown | 3 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 2 | 33% |
Unknown | 4 | 67% |