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Gene Function Analysis

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Cover of 'Gene Function Analysis'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 The Present State and Future Direction of Integrated Gene Function Analysis
  3. Altmetric Badge
    Chapter 2 Performing Integrative Functional Genomics Analysis in GeneWeaver.org
  4. Altmetric Badge
    Chapter 3 Functional Annotation of Differentially Regulated Gene Set Using WebGestalt: A Gene Set Predictive of Response to Ipilimumab in Tumor Biopsies.
  5. Altmetric Badge
    Chapter 4 Integrative Data-Mining Tools to Link Gene and Function
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    Chapter 5 Detection of Driver Protein Complexes in Breast Cancer Metastasis by Large-Scale Transcriptome–Interactome Integration
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    Chapter 6 Pattern Identification in Time-Course Gene Expression Data with the CoGAPS Matrix Factorization.
  8. Altmetric Badge
    Chapter 7 Statistical Tools and R Software for Cancer Driver Probabilities
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    Chapter 8 Predicting the functional consequences of somatic missense mutations found in tumors.
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    Chapter 9 Determining the effect of DNA methylation on gene expression in cancer cells.
  11. Altmetric Badge
    Chapter 10 Reverse Engineering Transcriptional Gene Networks
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    Chapter 11 Integrating in silico resources to map a signaling network.
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    Chapter 12 A method for inducible gene over-expression and down-regulation in emerging model species using pogostick.
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    Chapter 13 Construction and application of site-specific artificial nucleases for targeted gene editing.
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    Chapter 14 Selection of Recombinant Antibodies from Antibody Gene Libraries
  16. Altmetric Badge
    Chapter 15 Construction of Simple and Efficient siRNA Validation Systems for Screening and Identification of Effective RNAi-Targeted Sequences from Mammalian Genes
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    Chapter 16 Rapid Genetic Modification of Mouse Embryonic Stem Cells by Inducible Cassette Exchange Recombination
  18. Altmetric Badge
    Chapter 17 In Ovo Electroporation of miRNA-Based-Plasmids to Investigate Gene Function in the Developing Neural Tube
  19. Altmetric Badge
    Chapter 18 Proteomic Strategies: SILAC and 2D-DIGE—Powerful Tool to Investigate Cellular Alterations
  20. Altmetric Badge
    Chapter 19 Conditional gene-trap mutagenesis in zebrafish.
Attention for Chapter 3: Functional Annotation of Differentially Regulated Gene Set Using WebGestalt: A Gene Set Predictive of Response to Ipilimumab in Tumor Biopsies.
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  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

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Chapter title
Functional Annotation of Differentially Regulated Gene Set Using WebGestalt: A Gene Set Predictive of Response to Ipilimumab in Tumor Biopsies.
Chapter number 3
Book title
Gene Function Analysis
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-62703-721-1_3
Pubmed ID
Book ISBNs
978-1-62703-720-4, 978-1-62703-721-1
Authors

Stefan Kirov, Ruiru Ji, Jing Wang, Bing Zhang, Kirov, Stefan, Ji, Ruiru, Wang, Jing, Zhang, Bing

Abstract

Most high-throughput methods which are used in molecular biology generate gene lists. Interpreting large gene lists can reveal mechanistic insights and generate useful testable hypotheses. The process can be cumbersome and challenging. Multiple commercial and open solution currently exist that can aid researchers in the functional annotation of gene lists. The process of gene set annotation includes dataset preparation, which is method specific, gene list annotation and analysis and interpretation of the significant associations that were found. In this chapter, we demonstrate how WebGestalt can be applied to gene lists generated from transcriptional profiling data.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 36%
Student > Ph. D. Student 2 14%
Student > Master 2 14%
Student > Doctoral Student 1 7%
Professor > Associate Professor 1 7%
Other 0 0%
Unknown 3 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 36%
Medicine and Dentistry 3 21%
Biochemistry, Genetics and Molecular Biology 2 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Unknown 3 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2013.
All research outputs
#15,285,728
of 22,731,677 outputs
Outputs from Methods in molecular biology
#5,308
of 13,086 outputs
Outputs of similar age
#189,931
of 305,164 outputs
Outputs of similar age from Methods in molecular biology
#199
of 594 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,086 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,164 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 594 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.