Chapter title |
Enhanced cytotoxicity in mice of combinations of concanavalin A and selected antitumor drugs.
|
---|---|
Chapter number | 16 |
Book title |
Concanavalin A
|
Published in |
Advances in experimental medicine and biology, January 1975
|
DOI | 10.1007/978-1-4684-0949-9_16 |
Pubmed ID | |
Book ISBNs |
978-1-4684-0951-2, 978-1-4684-0949-9
|
Authors |
Bradley, S G, Marecki, N M, Bond, J S, Munson, A E, John, D T, Bradley, S. G., Marecki, N. M., Bond, J. S., Munson, A. E., John, D. T. |
Abstract |
Concanavalin A (Con A) injected intraperitoneally at a dose of 50 mg per kg was not lethal for male BALB/c mice. Six hours after administration of 5 mg Con A/kg, the proportioy 24 hr, the proportion of granulocytes had decreased to 56%. Adiministration of 5 mg Con A/kg 24 hr before 200 mg of 5[3,3-bis(2-chloroethyl)-triazeno]-imidazole-4-carboxamide per kg, or 100 mg of 5-fluorouracil per kg resulted in a significant enhancement of lethality. Simulatenous administration of 5 mg Con A/gm and 10 mg of daunomycin per kg also resulted in enhanced lethality. Administration of 5 mg Con A/kg 24 hr before 40 mg of 1,3-bis(2-chloroethyl)-1-nitrosourea per kg, 200 mg of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea per kg, 1000 mg of cytosine arabinoside per kg, 0.1 mg of mithramycin per kg, 2 mg of pactamycin per kg or 1 mg of vincristine per kg did not result in enhanced lethality. Lipid A prepared from Escherichia coli 0127:B8 Boivin lipopolysaccharide has been complexed to Con A. The lipid A-Con A complex (5mg/kg) was no more, or less effective in enhancing the lethality of 5-fluorouracil than 2.5 mg Con A/kg. The lipid A-Con A complex (40 mg/kg), given simultaneously with drug, enhanced lethality per kg. In this regard, the lipid A-Con A complex had vincristine per kg. In this regard, the lipid A-Con A complex had activity comparable to the complex formed between lipid A and bovine serum albumin. Conceivably, Con A can be used to enhance the susceptibility of neoplastic cells to phase-specific antitumor drugs, especially those acting on deoxyribonucleic acid synthesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 2 | 40% |
Professor | 1 | 20% |
Researcher | 1 | 20% |
Student > Bachelor | 1 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 1 | 20% |
Biochemistry, Genetics and Molecular Biology | 1 | 20% |
Immunology and Microbiology | 1 | 20% |
Economics, Econometrics and Finance | 1 | 20% |
Engineering | 1 | 20% |
Other | 0 | 0% |