| Chapter title |
Oxytocin and Prader-Willi Syndrome
|
|---|---|
| Chapter number | 28 |
| Book title |
Behavioral Pharmacology of Neuropeptides: Oxytocin
|
| Published in |
Current topics in behavioral neurosciences, January 2017
|
| DOI | 10.1007/7854_2017_28 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-963738-9, 978-3-31-963739-6
|
| Authors |
Anahid Kabasakalian, Casara J. Ferretti, Eric Hollander, Kabasakalian, Anahid, Ferretti, Casara J., Hollander, Eric |
| Abstract |
In the chapter, we explore the relationship between the peptide hormone, oxytocin (OT), and behavioral and metabolic disturbances observed in the genetic disorder Prader-Willi Syndrome (PWS). Phenotypic and genotypic characteristics of PWS are described, as are the potential implications of an abnormal OT system with respect to neural development including the possible effects of OT dysfunction on interactions with other regulatory mediators, including neurotransmitters, neuromodulators, and hormones. The major behavioral characteristics are explored in the context of OT dysfunction, including hyperphagia, impulsivity, anxiety and emotion dysregulation, sensory processing and interoception, repetitive and restrictive behaviors, and dysfunctional social cognition. Behavioral overlaps with autistic spectrum disorders are discussed. The implications of OT dysfunction on the mechanisms of reward and satiety and their possible role in informing behavioral characteristics are also discussed. Treatment implications and future directions for investigation are considered. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 9 | 15% |
| Student > Master | 7 | 11% |
| Researcher | 7 | 11% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Bachelor | 4 | 6% |
| Other | 9 | 15% |
| Unknown | 19 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 16 | 26% |
| Medicine and Dentistry | 13 | 21% |
| Nursing and Health Professions | 5 | 8% |
| Neuroscience | 2 | 3% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 21 | 34% |