Chapter 1 Introduction: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design

Chapter 2 Yeast Two-Hybrid Protein-Protein Interaction Networks

Chapter 3 The Use of Mass Spectrometry in Studying Protein-Protein Interaction

Chapter 4 Molecular Recognition in the Immune System

Chapter 5 Computational Methods for Predicting Protein-Protein Interactions

Chapter 6 Protein-Protein Docking Methods

Chapter 7 Thermochemistry of Binary and Ternary Protein Interactions Measured by Titration Calorimetry: Complex Formation of CD4, HIV gp120, and Anti-gp120

Chapter 8 Protein-Protein Recognition in Phosphotyrosine-Mediated Intracellular Signaling

Chapter 9 Competitive Binding of Proline-Rich Sequences by SH3, WW, and Other Functionally Related Protein Domains

Chapter 10 The Structure and Molecular Interactions of the Bromodomain

Chapter 12 Disrupting Protein-Protein Interaction: Therapeutic Tools Against Brain Damage

Chapter 13 A Thermodynamic Guide to Affinity Optimization of Drug Candidates