Biological Reactive Intermediates V

Table of Contents

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   Book Overview
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   Chapter 1 New Biological Reactive Intermediates
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   Chapter 2 Activation of Toxic Chemicals by Cytochrome P450 Enzymes
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   Chapter 3 Investigating the Role of the Microsomal Epoxide Hydrolase Membrane Topology and Its Implication for Drug Metabolism Pathways
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   Chapter 4 Cytotoxicity of Nitric Oxide and Hydrogen Peroxide
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   Chapter 5 Development of a Mass Spectrometric Assay for 5,6,7,9-Tetrahydro-7-Hydroxy-9-Oximidazo [1,2- a ]Purine in DNA Modified by 2-Chloro-Oxirane
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   Chapter 6 Reactions of Reactive Metabolites with Hemoproteins—Toxicological Implications
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   Chapter 7 Immunochemical Detection of Drug-Protein Adducts in Acetaminophen Hepatotoxicity
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   Chapter 8 An Oxidant Sensor at the Plasma Membrane
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    Chapter 9 Identification of Hydrogen Peroxide as the Relevant Messenger in the Activation Pathway of Transcription Factor NF-κB
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    Chapter 10 Redox Regulation of Ap-1
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    Chapter 11 The Transcription Factor TCF/Elk-1
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    Chapter 12 Some Activities of the Oxidant Chromate
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    Chapter 13 Reactive Dopamine Metabolites and Neurotoxicity
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    Chapter 14 Selective Depletion of Mitochondrial Glutathione Content by Pivalic Acid and Valproic Acid in Rat Liver
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    Chapter 15 Regulation of the Superoxide Releasing System in Human Fibroblasts
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    Chapter 16 Studies on the Mechanism of Phototoxicity of BAY y 3118 and Other Quinolones
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    Chapter 17 4-Oxo-Retinoic Acid Is Generated from Its Precursor Canthaxanthin and Enhances Gap Junctional Communication in 10T1/2 Cells
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    Chapter 18 Hepatic Epoxide Concentrations during Biotransformation of 1,2- and 1,4-Dichlorobenzene
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    Chapter 19 Oxygen Radical Formation Due to the Effect of Varying Hydrogen Ion Concentrations on Cytochrome P450-Catalyzed Cyclosporine Metabolism in Rat and Human Liver Microsomes
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    Chapter 20 Nitric Oxide Production in the Lung and Liver following Inhalation of the Pulmonary Irritant Ozone
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    Chapter 21 The Importance of Superoxide in Nitric Oxide-Dependent Toxicity
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    Chapter 22 Understanding the Structural Aspects of Neuronal Nitric Oxide Synthase (NOS) Using Microdissection by Molecular Cloning Techniques
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    Chapter 23 Molecular Mechanisms Regulating Nitric Oxide Biosynthesis
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    Chapter 24 DNA Damage and Nitric Oxide
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    Chapter 25 Inhibition of Cytochrome P450 Enzymes by Nitric Oxide
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    Chapter 26 NO as a Physiological Signal Molecule that Triggers Thymocyte Apoptosis
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    Chapter 27 Amplification of Nitric Oxide Synthase Expression by Nitric Oxide in Interleukin 1β-Stimulated Rat Mesangial Cells
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    Chapter 28 The Kidney as a Target for Biological Reactive Metabolites
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    Chapter 29 Reactive Intermediates of Xenobiotics in Thyroid
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    Chapter 30 Mechanisms of Cytochrome P450-Mediated Formation of Pneumotoxic Electrophiles
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    Chapter 31 Role of Free Radicals in Failure of Fatty Livers following Liver Transplantation and Alcoholic Liver Injury
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    Chapter 32 The Liver as Origin and Target of Reactive Intermediates Exemplified by the Progesterone Derivative, Cyproterone Acetate
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    Chapter 33 Studies on the Formation of Hepatic DNA Adducts by the Antiandrogenic and Gestagenic Drug, Cyproterone Acetate
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    Chapter 34 Mechanistic Studies of Benzene Toxicity — Implications for Risk Assessment
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    Chapter 35 Linking the Metabolism of Hydroquinone to Its Nephrotoxicity and Nephrocarcinogenicity
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    Chapter 36 Ethylene Oxide as a Biological Reactive Intermediate of Endogenous Origin
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    Chapter 37 Estrogen Metabolites as Bioreactive Modulators of Tumor Initiators and Promoters
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    Chapter 38 Biosynthesis and Cellular Effects of Toxic Glutathione S -Conjugates
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    Chapter 39 Acyl Glucuronides
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    Chapter 40 Benzene-Induced Bone Marrow Cell Depression Caused by Inhibition of the Conversion of Pre-Interleukins-1α and -1β to Active Cytokines by Hydroquinone, a Biological Reactive Metabolite of Benzene
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    Chapter 41 Sulfotransferase-Mediated Activation of Some Benzylic and Allylic Alcohols
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    Chapter 42 Application of Computational Chemistry in the Study of Biologically Reactive Intermediates
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    Chapter 43 Predicting the Regioselectivity and Stereoselectivity of Cytochrome P450-Mediated Reactions
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    Chapter 44 Electronic Models for Cytochrome P450 Oxidations
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    Chapter 45 Species Differences in Metabolism of 1,3-Butadiene
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    Chapter 46 Ovarian Toxicity and Metabolism of 4-Vinylcyclohexene and Analogues in B6C3F 1 Mice
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    Chapter 47 Mechanisms of nitrosamine bioactivation and carcinogenesis.
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    Chapter 48 Role of molecular biology in risk assessment.
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    Chapter 49 Human GSH-Transferase in Risk Assessment
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    Chapter 50 Comparative estimation of the neurotoxic risks of N-hexane and N-heptane in rats and humans based on the formation of the metabolites 2,5-hexanedione and 2,5-heptanedione.
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    Chapter 51 The Use of Data on Biologically Reactive Intermediates in Risk Assessment
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    Chapter 52 Metabolism of Aflatoxin B 1 by Human Hepatocytes in Primary Culture
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    Chapter 53 Induction of Cytochromes P450 by Dioxins in Liver and Lung of Marmoset Monkeys ( Callithrix jacchus )
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    Chapter 54 Aryl Hydrocarbon Receptor mRNA Levels in Different Tissues of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Responsive and Nonresponsive Mice
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    Chapter 55 Biomonitoring Workers Exposed to Arylamines