Chapter title |
Hyperoxaluria and rapid development of renal failure following a combined liver and kidney transplantation: emphasis on sequential transplantation.
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Chapter number | 67 |
Book title |
JIMD Reports - Case and Research Reports, 2011/3
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Published in |
JIMD Reports, September 2011
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DOI | 10.1007/8904_2011_67 |
Pubmed ID | |
Book ISBNs |
978-3-64-224935-8, 978-3-64-224936-5
|
Authors |
Alkhunaizi AM, Al-Sannaa NA, Raslan WF, Ahmed M. Alkhunaizi, Nouriya A. Al-Sannaa, Wasim F. Raslan, Alkhunaizi, Ahmed M., Al-Sannaa, Nouriya A., Raslan, Wasim F. |
Abstract |
Primary hyperoxaluria type I (PH I) is a rare genetic disorder that leads to end stage renal disease (ESRD) at an early age due to excessive deposition of calcium oxalate in the kidney. Combined liver-kidney transplantation (LKTx) has been advocated as the treatment of choice for patients with PH I who have progressive renal disease. With combined LKTx the risk of early renal failure secondary to oxalate deposition is anticipated. Here we report a patient with PH I who developed ESRD and underwent a combined LKTx. He lost the kidney graft secondary to early recurrence of oxalosis. Repeat kidney transplantation 13 months after the initial procedure was successful. Elevated plasma oxalate levels persisted for a long time following LKTx and lead to further deposition of oxalate in the second kidney graft. Combined LKTx for patients with PH I requires meticulous preparation and very careful post operative management. Sequential liver transplantation followed by kidney transplantation is to be considered for PH I patients who have ESRD and very high oxalate load. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 8 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 2 | 25% |
Other | 1 | 13% |
Student > Master | 1 | 13% |
Researcher | 1 | 13% |
Student > Postgraduate | 1 | 13% |
Other | 0 | 0% |
Unknown | 2 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 38% |
Agricultural and Biological Sciences | 2 | 25% |
Biochemistry, Genetics and Molecular Biology | 1 | 13% |
Unknown | 2 | 25% |